Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G1B | P04054 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 9/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 7/20 | 0.38 |
| ▸ | PPARD | Q03181 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1823517 | 0.84 | MAPT (0.40) | KMT2APPARARAB9ANPC1MAPT | |
| SCHEMBL1821328 | 0.79 | PPARG (0.39) | PPARASMN1; SMN2PPARG | |
| SCHEMBL1824801 | 0.77 | MCL1 (0.43) | KMT2ARAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL1820465 | 0.76 | KMT2A (0.38) | KMT2ARAB9ANPC1MAPTCASP3 | |
| SCHEMBL1820820 | 0.75 | POLB (0.38) | KMT2APPARAMAPTPPARGALDH1A1 | |
| SCHEMBL1822482 | 0.72 | BCHE (0.41) | SMN1; SMN2 | |
| SCHEMBL1820649 | 0.71 | KIF11 (0.45) | PPARAMAPTSMN1; SMN2PPARGPPARD | |
| SCHEMBL1819713 | 0.70 | MAOB (0.42) | KMT2AMAPT | |
| SCHEMBL1818643 | 0.68 | ALDH1A1 (0.44) | KMT2APPARAMAPTPPARGALDH1A1 | |
| SCHEMBL1819040 | 0.68 | MAPT (0.41) | KMT2APPARARAB9ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947712-B2 | Antiarthritic agents; asthma; chronic obstructive pulminary diosrders; atherosclerosis; vision defects; hepatitis; central nervous system disorders; cardiovascular disorders; wound healing agents; restenosis; cirrhosis; multiple sclerosis; glomerulonephritis; graft versus host disease; antidiabetic agent | WYETH LLC (US) | 2011-05-24 | — | — | US | disclosed |