Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.38 |
| ▸ | SELE | P16581 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1820714 | 0.88 | HDAC8 (0.43) | MCL1NPC1RAB9AMAPTKMT2A | |
| SCHEMBL1818671 | 0.85 | NPSR1 (0.43) | MCL1NPC1RAB9AMAPTKMT2A | |
| SCHEMBL1823517 | 0.83 | MAPT (0.40) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL1820465 | 0.81 | KMT2A (0.38) | NPC1RAB9AMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL1822482 | 0.79 | BCHE (0.41) | SMN1; SMN2 | |
| SCHEMBL1821328 | 0.79 | PPARG (0.39) | L3MBTL1SMN1; SMN2 | |
| SCHEMBL1820650 | 0.77 | PLA2G1B (0.42) | NPC1RAB9AMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL1820820 | 0.74 | POLB (0.38) | MAPTKMT2AMEN1L3MBTL1ALDH1A1 | |
| SCHEMBL1820711 | 0.73 | MCL1 (0.43) | MCL1NPC1RAB9AMAPTKMT2A | |
| SCHEMBL1819040 | 0.73 | MAPT (0.41) | NPC1RAB9AMAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947712-B2 | Antiarthritic agents; asthma; chronic obstructive pulminary diosrders; atherosclerosis; vision defects; hepatitis; central nervous system disorders; cardiovascular disorders; wound healing agents; restenosis; cirrhosis; multiple sclerosis; glomerulonephritis; graft versus host disease; antidiabetic agent | WYETH LLC (US) | 2011-05-24 | — | — | US | disclosed |