Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | TXNRD1 | Q16881 | 3/20 | 0.35 |
| ▸ | TXNRD3 | Q86VQ6 | 3/20 | 0.35 |
| ▸ | TXNRD2 | Q9NNW7 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.31 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.31 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2418995 | 0.86 | MAPT (0.42) | MAPTALDH1A1TDP1TXNRD1TXNRD3 | |
| SCHEMBL12170150 | 0.85 | MAPT (0.39) | MAPTTXNRD1TXNRD3TXNRD2KMT2A | |
| SCHEMBL13219689 | 0.82 | MAPT (0.40) | MAPTALDH1A1TDP1TXNRD1TXNRD3 | |
| SCHEMBL5708807 | 0.81 | MAPT (0.39) | MAPTTXNRD1TXNRD3TXNRD2KMT2A | |
| SCHEMBL14123560 | 0.78 | MAPT (0.46) | MAPTALDH1A1TDP1TXNRD1TXNRD3 | |
| SCHEMBL19456660 | 0.76 | MAPT (0.36) | MAPTALDH1A1TXNRD1TXNRD3TXNRD2 | |
| SCHEMBL5655492 | 0.75 | MEN1 (0.32) | MAPTKMT2AMEN1 | |
| SCHEMBL15624647 | 0.75 | MAPT (0.44) | MAPTALDH1A1TDP1TXNRD1TXNRD3 | |
| SCHEMBL29366803 | 0.73 | CYP1A2 (0.42) | MAPTALDH1A1TDP1CYP1A2KMT2A | |
| SCHEMBL9168661 | 0.71 | CYP1A2 (0.48) | MAPTALDH1A1TDP1CYP1A2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016177449-A1 | THIADIAZOLOQUINOXALINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-11-10 | — | — | WO | disclosed |