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Sugi Predict / Compounds / SCHEMBL18220255

SCHEMBL18220255

SCHEMBL18220255

CCC(O)CNC(=O)/C(C#N)=C(\C)c1ccc(-c2ccc3cc(N(CC)CC)ccc3c2)o1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CTSS P25774 2/20 0.36
▸ CTSK P43235 2/20 0.36
▸ KMT2A Q03164 7/20 0.35
▸ MEN1 O00255 6/20 0.35
▸ MAPT P10636 6/20 0.35
▸ ATM Q13315 3/20 0.35
▸ MAOB P27338 3/20 0.35
▸ USP2 O75604 1/20 0.35
▸ CYP1A2 P05177 1/20 0.35
▸ CYP2C19 P33261 1/20 0.35
▸ TDP1 Q9NUW8 2/20 0.35
▸ ALDH1A1 P00352 4/20 0.33
▸ KDM4E B2RXH2 3/20 0.33
▸ HPGD P15428 2/20 0.33
▸ SMN1; SMN2 Q16637 2/20 0.33
▸ ALOX15 P16050 2/20 0.33
▸ SLC16A3 O15427 1/20 0.33
▸ SLC16A1 P53985 1/20 0.33
▸ HSD17B10 Q99714 1/20 0.33
▸ DHODH Q02127 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17120667 0.95 CTSS (0.35) CTSSCTSKKMT2AMEN1MAPT
SCHEMBL18220250 0.93 NPSR1 (0.32) CTSSCTSKDHODHERN1L3MBTL1
SCHEMBL18220260 0.93 DHODH (0.32) KMT2AMEN1MAPTUSP2TDP1
SCHEMBL17120680 0.88 NPSR1 (0.31) ERN1L3MBTL1
SCHEMBL24068493 0.87 CTSS (0.31) CTSSCTSKDHODHERN1
SCHEMBL18220143 0.86 KMT2A (0.36) CTSSCTSKKMT2AMEN1MAPT
SCHEMBL17120678 0.86 HPGD (0.31) KMT2AMEN1USP2TDP1ALDH1A1
SCHEMBL19293892 0.85 SCN9A (0.35) CTSSCTSKKMT2AMEN1MAPT
SCHEMBL23134915 0.83 KMT2A (0.40) KMT2AMEN1MAPTATMMAOB
SCHEMBL18220259 0.82 APP (0.35) CTSSCTSKKMT2AMEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240208916-A1 AMYLOID TARGETING AGENTS AND METHODS OF USING THE SAME Amydis, Inc. 2024-06-27 — — US disclosed
US-11718596-B2 Amyloid targeting agents and methods of using the same THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2023-08-08 — — US disclosed
US-10005745-B2 Amyloid targeting agents and methods of using the same THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2018-06-26 — — US disclosed
US-20170248616-A1 IN VITRO COMPOSITIONS COMPRISING HUMAN SAMPLE AND AMYLOID TARGETING AGENT Amydis, Inc. 2017-08-31 — — US disclosed
US-20160326126-A1 AMYLOID TARGETING AGENTS AND METHODS OF USING THE SAME Amydis, Inc. 2016-11-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11718596-B2 Amyloid targeting agents and methods of using the same APP, CRYAA, APBA1 CTSS 1365/4885CTSK 1830/4885KMT2A 4649/4885
US-20240208916-A1 AMYLOID TARGETING AGENTS AND METHODS OF USING THE SAME APP, CRYAA, APBA1 CTSS 1365/4885CTSK 1830/4885KMT2A 4649/4885
US-20160326126-A1 AMYLOID TARGETING AGENTS AND METHODS OF USING THE SAME APP, APBA1, CRYAA CTSS 1434/4885CTSK 1825/4885KMT2A 4621/4885
US-10005745-B2 Amyloid targeting agents and methods of using the same APP, APBA1, CRYAA CTSS 1434/4885CTSK 1825/4885KMT2A 4621/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.