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Sugi Predict / Compounds / SCHEMBL18220263

SCHEMBL18220263

SCHEMBL18220263

CCC(O)CNS(=O)(=O)/C(C#N)=C(\C)c1ccc(-c2ccc3cc(N4CCN(C)CC4)ccc3c2)o1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ OPRM1 P35372 3/20 0.37
▸ OPRD1 P41143 3/20 0.37
▸ MAPKAPK2 P49137 1/20 0.36
▸ MEN1 O00255 1/20 0.36
▸ APAF1 O14727 1/20 0.36
▸ MAPK1 P28482 1/20 0.36
▸ KMT2A Q03164 1/20 0.36
▸ SMN1; SMN2 Q16637 1/20 0.36
▸ NPSR1 Q6W5P4 1/20 0.36
▸ MAP4K4 O95819 1/20 0.35
▸ TNIK Q9UKE5 1/20 0.35
▸ ERN1 O75460 1/20 0.34
▸ ALDH1A1 P00352 1/20 0.34
▸ MAPT P10636 1/20 0.34
▸ RAD52 P43351 1/20 0.34
▸ APP P05067 1/20 0.34
▸ CTSK P43235 3/20 0.34
▸ CTSB P07858 1/20 0.34
▸ KCNH2 Q12809 1/20 0.33
▸ CSF1R P07333 5/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17120662 0.94 OPRM1 (0.37) OPRM1OPRD1MAPKAPK2MEN1APAF1
SCHEMBL18220257 0.93 APP (0.33) MEN1MAPK1KMT2ASMN1; SMN2ALDH1A1
SCHEMBL18220254 0.92 MAPT (0.36) MEN1MAPK1KMT2ASMN1; SMN2ERN1
SCHEMBL17120668 0.87 APP (0.33) MEN1KMT2AMAPTAPPCSF1R
SCHEMBL24075180 0.86 APP (0.41) OPRM1OPRD1MAPKAPK2MEN1APAF1
SCHEMBL18221443 0.86 SYK (0.37) MEN1KMT2ASMN1; SMN2ERN1MAPT
SCHEMBL18220148 0.86 APP (0.43) OPRM1OPRD1MAPKAPK2MEN1APAF1
SCHEMBL18220032 0.84 NPC1 (0.38) MEN1KMT2ASMN1; SMN2ALDH1A1MAPT
SCHEMBL18220261 0.83 OPRM1 (0.40) OPRM1OPRD1MAPKAPK2MEN1APAF1
SCHEMBL18220237 0.83 APP (0.36) OPRM1OPRD1ALDH1A1MAPTAPP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240208916-A1 AMYLOID TARGETING AGENTS AND METHODS OF USING THE SAME Amydis, Inc. 2024-06-27 — — US disclosed
US-11718596-B2 Amyloid targeting agents and methods of using the same THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2023-08-08 — — US disclosed
US-10005745-B2 Amyloid targeting agents and methods of using the same THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2018-06-26 — — US disclosed
US-20170248616-A1 IN VITRO COMPOSITIONS COMPRISING HUMAN SAMPLE AND AMYLOID TARGETING AGENT Amydis, Inc. 2017-08-31 — — US disclosed
US-20160326126-A1 AMYLOID TARGETING AGENTS AND METHODS OF USING THE SAME Amydis, Inc. 2016-11-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11718596-B2 Amyloid targeting agents and methods of using the same APP, CRYAA, APBA1 OPRM1 4377/4885OPRD1 4481/4885MAPKAPK2 3280/4885
US-20240208916-A1 AMYLOID TARGETING AGENTS AND METHODS OF USING THE SAME APP, CRYAA, APBA1 OPRM1 4377/4885OPRD1 4481/4885MAPKAPK2 3280/4885
US-20160326126-A1 AMYLOID TARGETING AGENTS AND METHODS OF USING THE SAME APP, APBA1, CRYAA OPRM1 4421/4885OPRD1 4497/4885MAPKAPK2 3269/4885
US-10005745-B2 Amyloid targeting agents and methods of using the same APP, APBA1, CRYAA OPRM1 4421/4885OPRD1 4497/4885MAPKAPK2 3269/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.