Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.38 |
| ▸ | CCNK | O75909 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CCND3 | P30281 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 2/20 | 0.38 |
| ▸ | CTSC | P53634 | 6/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12713915 | 0.77 | BCL6 (0.57) | KDRLRRK2CCNKCCNA2CDK2 | |
| SCHEMBL28223543 | 0.73 | JAK2 (0.62) | KDRLRRK2CDK2IGF1RCTSC | |
| SCHEMBL31143287 | 0.71 | KDR (0.51) | KDRMEN1ALDH1A1MAPTRAB9A | |
| SCHEMBL14127502 | 0.71 | KDR (0.51) | KDRMEN1ALDH1A1MAPTRAB9A | |
| SCHEMBL21365048 | 0.70 | STK17A (0.58) | KDRCCNA2CDK2MEN1ALDH1A1 | |
| SCHEMBL14670652 | 0.70 | MEN1 (0.52) | KDRLRRK2CDK9IGF1RJAK2 | |
| SCHEMBL4901278 | 0.69 | KDR (0.46) | KDRMEN1ALDH1A1MAPTRAB9A | |
| SCHEMBL2229315 | 0.68 | NPC1 (0.44) | KDRCDK2CDK1MAPTMAPK1 | |
| SCHEMBL28857802 | 0.65 | MAPK10 (0.47) | KDRMEN1ALDH1A1GAAMAPT | |
| SCHEMBL16820257 | 0.65 | GRM4 (0.43) | KDRIGF1RJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2315751-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | Amgen Inc. (US) | 2011-05-04 | — | — | EP | disclosed |
| WO-2009158011-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2009-12-30 | — | — | WO | disclosed |