Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 6/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.49 |
| ▸ | AURKA | O14965 | 5/20 | 0.49 |
| ▸ | IGF1R | P08069 | 5/20 | 0.49 |
| ▸ | JAK3 | P52333 | 5/20 | 0.49 |
| ▸ | PAK4 | O96013 | 4/20 | 0.49 |
| ▸ | KDR | P35968 | 4/20 | 0.49 |
| ▸ | PLK4 | O00444 | 3/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.49 |
| ▸ | RET | P07949 | 2/20 | 0.49 |
| ▸ | FLT3 | P36888 | 2/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.49 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.49 |
| ▸ | STK10 | O94804 | 1/20 | 0.49 |
| ▸ | FER | P16591 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14670395 | 0.79 | IGF1R (0.60) | IGF1R | |
| SCHEMBL4005596 | 0.74 | MEN1 (0.59) | MEN1HTTKMT2AHSD17B10JAK2 | |
| SCHEMBL218642 | 0.74 | MEN1 (0.62) | MEN1HTTKMT2AHSD17B10JAK2 | |
| SCHEMBL17501771 | 0.74 | ITK (0.50) | MEN1HTTKMT2AHSD17B10JAK2 | |
| SCHEMBL3939475 | 0.73 | PAK4 (0.56) | MEN1HTTKMT2AHSD17B10JAK2 | |
| SCHEMBL29784035 | 0.72 | JAK2 (0.57) | MEN1HTTKMT2AHSD17B10JAK2 | |
| SCHEMBL3869550 | 0.70 | ITK (0.51) | MEN1HTTKMT2AHSD17B10JAK2 | |
| SCHEMBL4168909 | 0.70 | IKBKB (0.46) | MEN1HTTKMT2AHSD17B10JAK2 | |
| SCHEMBL1822366 | 0.70 | KDR (0.42) | MEN1KMT2AJAK2AURKAIGF1R | |
| SCHEMBL4164963 | 0.69 | MEN1 (0.49) | MEN1HTTKMT2AHSD17B10AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013014162-A1 | HETEROCYCLYL PYRIMIDINE ANALOGUES AS JAK INHIBITORS | CELLZOME LIMITED (GB) | 2013-01-31 | — | — | WO | disclosed |