Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 5/20 | 0.47 |
| ▸ | TERT | O14746 | 2/20 | 0.47 |
| ▸ | APAF1 | O14727 | 1/20 | 0.38 |
| ▸ | TCF4 | P15884 | 1/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 2/20 | 0.34 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18227090 | 0.89 | APP (0.47) | APPTERTAPAF1TCF4CTNNB1 | |
| SCHEMBL16739391 | 0.84 | TERT (0.49) | APPTERTAPAF1BACE1EGFR | |
| SCHEMBL16739383 | 0.83 | APP (0.50) | APPTERTAPAF1TCF4CTNNB1 | |
| SCHEMBL18227073 | 0.81 | TERT (0.47) | APPTERTAPAF1BACE1EGFR | |
| SCHEMBL18227142 | 0.80 | APP (0.50) | APPTERTAPAF1TCF4CTNNB1 | |
| SCHEMBL16739384 | 0.80 | TERT (0.46) | APPTERTPSMB5 | |
| SCHEMBL18227144 | 0.79 | TERT (0.49) | APPTERTAPAF1BACE1EGFR | |
| SCHEMBL18226916 | 0.78 | APP (0.47) | APPTERTAPAF1TCF4CTNNB1 | |
| SCHEMBL18227093 | 0.73 | TERT (0.49) | APPTERTAPAF1EGFRNOS1 | |
| SCHEMBL18227070 | 0.73 | TERT (0.49) | APPTERTAPAF1BACE1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160332971-A1 | ARYLQUINOLINE, ARYLQUINOLONE AND ARYLTHIOQUINOLONE DERIVATIVES AND USE THEREOF TO TREAT CANCER | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2016-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160332971-A1 | ARYLQUINOLINE, ARYLQUINOLONE AND ARYLTHIOQUINOLONE DERIVATIVES AND USE THEREOF TO TREAT CANCER | CASP4, PARP14, API5 | APP 2258/4885TERT 1541/4885APAF1 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.