CASP4 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1123752	0.60	8/20
SCHEMBL2772556	0.61	7/20
SCHEMBL2813450	0.48	7/20
Tirilazad (SCHEMBL483318)	0.79	6/20
SCHEMBL2771547	0.59	6/20
SCHEMBL1091086	0.59	6/20
SCHEMBL2773410	0.56	6/20
SCHEMBL2807024	0.55	6/20
SCHEMBL2808318	0.54	6/20
SCHEMBL1124029	0.49	6/20
Hydrochloric Acid (SCHEMBL3092488)	0.54	5/20
SCHEMBL2038060	0.63	4/20
SCHEMBL2808295	0.49	4/20
Tirilazad (SCHEMBL1650168)	0.74	3/20
Tirilazad (SCHEMBL49410)	0.73	3/20
SCHEMBL2038936	0.55	3/20
SCHEMBL2039051	0.55	3/20
SCHEMBL2744129	0.54	3/20
SCHEMBL614741	0.54	3/20
SCHEMBL2744395	0.53	3/20

Clinical trials — most relevant to CASP4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Can Vitamin D Reduce Heart Muscle Damage After Bypass Surgery?	PHASE4	COMPLETED
Dexmedetomidine to Prevent Hepatic Ischemia-reperfusion Injury-induced Glycocalyx Degradation and Early Allograft Dysfunction in Liver Transplantation	PHASE4	ACTIVE_NOT_RECRUITING
Strategies to Reduce Organic Muscle Atrophy in the Intensive Care Unit	PHASE2/PHASE3	WITHDRAWN
Minocycline for the Treatment of Early-Phase Schizophrenia	PHASE3	COMPLETED
Disulfiram in Rheumatoid Arthritis	PHASE2	NOT_YET_RECRUITING
Atorvastatin Calcium, Oligofructose-Enriched Inulin, or Sulindac in Preventing Cancer in Patients at Increased Risk of Developing Colorectal Neoplasia	PHASE2	COMPLETED
Safety, Tolerability, and Treatment Effect of Belnacasan in Patients With COVID-19	PHASE2	COMPLETED
Hydroxychloroquine to Increase Tumor Suppressor PAR-4 Levels in Oligometastatic Prostate Cancer	PHASE2	COMPLETED
Safety and Efficacy Study of a Caspase Inhibitor in Patients Undergoing Liver Transplantation	PHASE2	COMPLETED
Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival	PHASE1	UNKNOWN
Circulating Markers for Ischemic Heart Disease	nan	RECRUITING
Impact of CASP3 Gene in Chemoresistance	nan	NOT_YET_RECRUITING
Evaluation of Serum Gasdermin D Level As a Potential Biomarker of Disease Activity in Vitiligo Patients	nan	UNKNOWN
Characterization of Non-canonical Way in Inflammasome Monocytes of Patients With Severe Sepsis	nan	COMPLETED
Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure	nan	RECRUITING
Apoptosis Markers in Aggressive Periodontitis	nan	COMPLETED
Analysis of the Variation in Caspase-8 Availability and Cleavage in Oral Squamous Cell Carcinoma	nan	UNKNOWN
New Signaling Pathway Targeting Systemic Lupus Erythematosus	nan	UNKNOWN
Role of Serum ADAM 17 (A Disintegrin And Metalloprotease 17) and Caspase 3 in Patients With Chronic Kidney Disease	nan	NOT_YET_RECRUITING
Effect of Periodontal Treatment on Inflammasome Proteins in Periodontal Diseases	nan	UNKNOWN
Apoptosis May Have a Role in Etiopathogenesis of Obstetric Cholestasis.	nan	UNKNOWN
Inflammasomes in Cell Death in FTMH, ERM, and RRD	nan	COMPLETED
Early Diagnosis and Prognosis of Postoperative Sepsis by Presepsin and Syndecan-1	nan	UNKNOWN
The Mechanisms and Significances of Synergistic Effects of Mycophenolic Acid and LPS on IL-1β Secretion by Mononuclear	nan	UNKNOWN
Role NLRP3 Inflammasome in Weight Loss Following Sleeve Gastrectomy in Morbidly Obese Patients	nan	UNKNOWN
The Effect of Vitamin E-coated Polysulfone Membrane on Oxidative Stress, Inflammation and Monocytes in Critically Ill Patients in CRRT	nan	UNKNOWN
The Role of Pyroptosis in Chronic Venous Disease	nan	UNKNOWN
Gene Expression Profiles in Patients With Permanent Atrial Fibrillation (AF) Versus Sinus Rhythm (SR)	nan	UNKNOWN
Neutrophils as Prognostic Factors in Granulomatosis With Polyangiitis (Formerly Named Wegener's Granulomatosis)	nan	COMPLETED
Evaluation of Inflammasome Gene Polymorphisms in Periodontitis Patients	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a CASP4 binder may also engage these)

Protein	Name	Similarity
O75601	—	0.993	O75601 →
Q5E9C1	—	0.988	Q5E9C1 →
Q9MZV6	—	0.981	Q9MZV6 →
Q9N2I1	—	0.978	Q9N2I1 →
Q9MZV7	—	0.976	Q9MZV7 →
CASP12	Inactive caspase-12 (CASP-12)	0.975	landscape →
CASP1	Caspase-1	0.974	landscape →
Q075B4	—	0.972	Q075B4 →
Q153Z0	—	0.971	Q153Z0 →
P29452	—	0.969	P29452 →
Q9TV13	—	0.967	Q9TV13 →
P43527	—	0.966	P43527 →
CASP5	Caspase-5	0.964	landscape →
P70343	—	0.961	P70343 →
Q920D5	—	0.945	Q920D5 →
O08736	—	0.944	O08736 →
CASP8	Caspase-8	0.935	landscape →
Q4AC99	—	0.929	Q4AC99 →
Q9GZY0	—	0.924	Q9GZY0 →
Q0PF16	—	0.923	Q0PF16 →
Q2YEN2	—	0.923	Q2YEN2 →
MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.923	landscape →
Q2YEM8	—	0.922	Q2YEM8 →
Q5D7J1	—	0.921	Q5D7J1 →
Q587N6	—	0.921	Q587N6 →
Q2YEM9	—	0.921	Q2YEM9 →
Q5D7I9	—	0.921	Q5D7I9 →
Q8IYM9	—	0.920	Q8IYM9 →
Q1ACD7	—	0.920	Q1ACD7 →
Q1ACD8	—	0.920	Q1ACD8 →