Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 6/20 | 0.33 |
| ▸ | DRD3 | P35462 | 6/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
| ▸ | STS | P08842 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | OXTR | P30559 | 1/20 | 0.31 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | QPCT | Q16769 | 1/20 | 0.30 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1819154 | 0.95 | MAPK1 (0.41) | MAPK1NAMPTDRD2DRD3ADORA1 | |
| SCHEMBL1820549 | 0.76 | CXCR2 (0.46) | DRD2DRD3CXCR2STSHSD11B1 | |
| SCHEMBL3575588 | 0.76 | CXCR2 (0.46) | DRD2DRD3CXCR2STSHSD11B1 | |
| SCHEMBL3575587 | 0.76 | CXCR2 (0.46) | DRD2DRD3CXCR2STSHSD11B1 | |
| SCHEMBL28797392 | 0.75 | CXCR2 (0.49) | MAPK1CXCR2STSHSD11B1CXCR1 | |
| SCHEMBL13437620 | 0.71 | DRD2 (0.45) | MAPK1DRD2DRD3LMNA | |
| SCHEMBL1820473 | 0.70 | SCN9A (0.43) | — | |
| SCHEMBL3582529 | 0.69 | CXCR2 (0.45) | MAPK1ADORA1CXCR2STSHSD11B1 | |
| SCHEMBL3584598 | 0.69 | CXCR2 (0.47) | CXCR2HSD11B1CXCR1 | |
| SCHEMBL3575188 | 0.67 | CXCR2 (0.58) | MAPK1CXCR2HSD11B1CXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2316820-A1 | 2-aryl-propionamide derivatives useful as bradykinin receptor antagonists and pharmaceutical compositions containing them | Dompe S.p.A. (IT) | 2011-05-04 | — | — | EP | disclosed |