SCHEMBL18229441

SCHEMBL18229441

CC(C)c1ccc(NC(=O)Cc2c[nH]c3ccccc23)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 4/20 0.65
STING1 Q86WV6 1/20 0.62
MAPT P10636 6/20 0.61
ALDH1A1 P00352 5/20 0.61
LMNA P02545 2/20 0.61
MEN1 O00255 2/20 0.61
KMT2A Q03164 2/20 0.61
HTT P42858 2/20 0.61
ALOX12 P18054 1/20 0.61
TDP1 Q9NUW8 1/20 0.61
CFTR P13569 1/20 0.60
HDAC1 Q13547 3/20 0.56
STAT3 P40763 1/20 0.54
RAB9A P51151 1/20 0.54
HSD17B10 Q99714 1/20 0.54
CYP1A2 P05177 1/20 0.54
POLB P06746 1/20 0.54
CYP3A4 P08684 1/20 0.54
CYP2D6 P10635 1/20 0.54
CYP2C9 P11712 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25802387 0.89 HRH3 (0.66) HRH3MAPTALDH1A1LMNAMEN1
SCHEMBL613949 0.86 STING1 (0.55) HRH3STING1MAPTALDH1A1LMNA
SCHEMBL11189753 0.86 HRH3 (0.67) HRH3STING1MAPTALDH1A1LMNA
SCHEMBL18229442 0.86 HRH3 (0.69) HRH3STING1MAPTALDH1A1MEN1
SCHEMBL7807900 0.85 HRH3 (0.67) HRH3MAPTALDH1A1LMNAMEN1
SCHEMBL31218207 0.85 HRH3 (0.67) HRH3MAPTALDH1A1LMNAMEN1
SCHEMBL4435112 0.85 KMT2A (0.63) HRH3MAPTALDH1A1LMNAMEN1
SCHEMBL27333111 0.84 HRH3 (0.67) HRH3MAPTALDH1A1LMNAMEN1
SCHEMBL18229439 0.84 HRH3 (0.77) HRH3STING1MAPTALDH1A1LMNA
SCHEMBL18229461 0.83 HRH3 (0.65) HRH3STING1MAPTALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016181414-A1 PROCESS FOR THE SYNTHESIS OF IVACAFTOR AND RELATED COMPOUNDS COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2016-11-17 WO claimed
WO-2016181414-A1 PROCESS FOR THE SYNTHESIS OF IVACAFTOR AND RELATED COMPOUNDS COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2016-11-17 WO disclosed