Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | FNTA | P49354 | 1/20 | 0.38 |
| ▸ | FNTB | P49356 | 1/20 | 0.38 |
| ▸ | PTPRF | P10586 | 1/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1824983 | 0.93 | CYP2C9 (0.41) | MEN1KMT2AMAPTTP53POLB | |
| SCHEMBL1826130 | 0.90 | TP53 (0.44) | MEN1KMT2AMAPTTP53POLB | |
| SCHEMBL1825505 | 0.88 | ALDH1A1 (0.40) | MEN1KMT2AMAPTTP53POLB | |
| SCHEMBL1822442 | 0.88 | TP53 (0.42) | MEN1KMT2AMAPTTP53POLB | |
| SCHEMBL1826315 | 0.88 | TP53 (0.42) | MEN1KMT2AMAPTTP53POLB | |
| SCHEMBL1826051 | 0.87 | TP53 (0.36) | MEN1KMT2AMAPTTP53POLB | |
| SCHEMBL1824783 | 0.87 | MAPT (0.44) | MEN1KMT2AMAPTTP53POLB | |
| SCHEMBL1823959 | 0.87 | TP53 (0.48) | MEN1KMT2AMAPTTP53POLB | |
| SCHEMBL1823558 | 0.86 | MAPT (0.35) | MEN1KMT2AMAPTTP53POLB | |
| SCHEMBL1822579 | 0.86 | TP53 (0.41) | MEN1KMT2AMAPTTP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794122-B1 | 3-SUBSTITUTED-5- AND 6-AMINOALKYL INDOLE-2-CARBOXYLIC ACID AMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I | AVENTIS PHARMA INC (US) | 2011-05-04 | — | — | EP | claimed |