SCHEMBL18237306

SCHEMBL18237306

C#CCOCCOCCOCCOCCOCCOCCNC(=O)CC[C@@H](N)C(=O)OC(C)(C)C

nearest known ligand 0.39

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.34
PLK1 P53350 1/20 0.32
TSHR P16473 1/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
CA12 O43570 2/20 0.31
CA1 P00915 2/20 0.31
CA2 P00918 2/20 0.31
CA4 P22748 2/20 0.31
CA9 Q16790 2/20 0.31
CA14 Q9ULX7 2/20 0.31
ALDH1A1 P00352 2/20 0.31
TAAR1 Q96RJ0 1/20 0.31
GLP1R P43220 3/20 0.30
TLR2 O60603 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30097254 1.00 LTA4H (0.39) LTA4HL3MBTL1PLK1TSHRMEN1
SCHEMBL21380714 0.89 LTA4H (0.34) LTA4HPLK1
SCHEMBL24811754 0.85 LTA4H (0.41) LTA4HPLK1MEN1KMT2ACA12
SCHEMBL16049363 0.85 MEN1 (0.43) LTA4HPLK1MEN1KMT2ACA12
SCHEMBL22301077 0.85 LTA4H (0.41) LTA4HPLK1MEN1KMT2ACA12
SCHEMBL16049361 0.85 MEN1 (0.43) LTA4HPLK1MEN1KMT2ACA12
SCHEMBL17316220 0.84 LTA4H (0.43) LTA4HPLK1MEN1KMT2ACA12
SCHEMBL19125874 0.83 TSHR (0.40) LTA4HTSHRKMT2ACA12CA1
SCHEMBL30097280 0.82 LTA4H (0.34) LTA4H
SCHEMBL23080572 0.82 LTA4H (0.39) LTA4HPLK1MEN1KMT2ACA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230000993-A1 SILICON BASED DRUG CONJUGATES AND METHODS OF USING SAME BLINKBIO INC (US) 2023-01-05 US disclosed
US-20230000993-A1 SILICON BASED DRUG CONJUGATES AND METHODS OF USING SAME BLINKBIO INC (US) 2023-01-05 US disclosed
US-11291731-B2 Silicon based drug conjugates and methods of using same BLINKBIO, INC. (US) 2022-04-05 US disclosed
US-20190290771-A1 SILICON BASED DRUG CONJUGATES AND METHODS OF USING SAME BLINKBIO, INC. 2019-09-26 US disclosed
US-20190290771-A1 SILICON BASED DRUG CONJUGATES AND METHODS OF USING SAME BLINKBIO, INC. 2019-09-26 US disclosed
US-9931407-B2 Silicon based drug conjugates and methods of using same BLINKBIO, INC. (US) 2018-04-03 US disclosed
US-20170202970-A1 SILICON BASED DRUG CONJUGATES AND METHODS OF USING SAME BLINKBIO, INC. 2017-07-20 US disclosed
WO-2016183359-A1 SILICON BASED DRUG CONJUGATES AND METHODS OF USING SAME BLINKBIO, INC. (US) 2016-11-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170202970-A1 SILICON BASED DRUG CONJUGATES AND METHODS OF USING SAME CD44, MSN, AS3MT LTA4H 4189/4885L3MBTL1 669/4885PLK1 229/4885
US-11291731-B2 Silicon based drug conjugates and methods of using same CD44, MSN, AS3MT LTA4H 4189/4885L3MBTL1 669/4885PLK1 229/4885
US-20190290771-A1 SILICON BASED DRUG CONJUGATES AND METHODS OF USING SAME CD44, MSN, AS3MT LTA4H 4189/4885L3MBTL1 669/4885PLK1 229/4885
US-20230000993-A1 SILICON BASED DRUG CONJUGATES AND METHODS OF USING SAME CD44, MSN, AS3MT LTA4H 4189/4885L3MBTL1 669/4885PLK1 229/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.