SCHEMBL1823892

SCHEMBL1823892

Cc1cc(C(O)c2csc(C)c2)cs1

nearest known ligand 0.41

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
DAO P14920 1/20 0.41
TP53 P04637 1/20 0.34
HTR1A P08908 1/20 0.34
HPGD P15428 1/20 0.32
MAPK1 P28482 1/20 0.32
LMNA P02545 1/20 0.30
NPC1 O15118 1/20 0.30
RAB9A P51151 1/20 0.30
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21912502 0.85
SCHEMBL29413694 0.83
SCHEMBL24804465 0.81
SCHEMBL19967423 0.78 DAO (0.36) DAOTP53HTR1ALMNANPC1
SCHEMBL491464 0.77
SCHEMBL23057952 0.73
SCHEMBL8470678 0.73
SCHEMBL19967453 0.73 L3MBTL1 (0.36) DAOTP53HTR1AMAPK1
SCHEMBL24925866 0.73 ABCB11 (0.37) DAOTP53HTR1AHPGDMAPK1
SCHEMBL8082518 0.72 DAO (0.48) DAOHPGDMAPK1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1854804-B1 Heterocyclic metallocene compounds and use thereof in catalyst systems for producing olefin polymers BASELL POLYOLEFINE GMBH (DE) 2011-05-04 EP disclosed
EP-1854804-A1 Heterocyclic metallocene compounds and use thereof in catalyst systems for producing olefin polymers Basell Polyolefine GmbH (DE) 2007-11-14 EP disclosed
EP-1157027-B1 HETEROCYCLIC METALLOCENE COMPOUNDS AND USE THEREOF IN CATALYST SYSTEMS FOR PRODUCING OLEFIN POLYMERS BASELL POLYOLEFINE GMBH (DE) 2007-09-19 EP disclosed
US-7112638-B2 Hetero cyclic metallocene compounds and use thereof in catalyst system for producing olefin polymers BASELL POLYOLEFINE GMBH (DE) 2006-09-26 US disclosed
EP-1226193-B1 PROCESS FOR THE PREPARATION OF ETHYLENE POLYMERS BASELL POLYOLEFINE GMBH (DE) 2006-07-19 EP disclosed
US-6864333-B2 Process for the preparation of ethylene polymers BASEL POLYOLEFINE GMBH (DE) 2005-03-08 US disclosed
US-20030036612-A1 Hetero cyclic metallocene compounds and use thereof in catalyst system for producing olefin polymers BASELL POLYOLEFINE GMBH (DE) 2003-02-20 US disclosed
US-20020198339-A1 Process for the preparation of ethylene polymers EQUISTAR CHEMICALS, LP 2002-12-26 US disclosed
EP-1226193-A2 PROCESS FOR THE PREPARATION OF ETHYLENE POLYMERS Basell Technology Company B.V. (NL) 2002-07-31 EP disclosed
EP-1157027-A1 HETEROCYCLIC METALLOCENE COMPOUNDS AND USE THEREOF IN CATALYST SYSTEMS FOR PRODUCING OLEFIN POLYMERS Basell Technology Company B.V. (NL) 2001-11-28 EP disclosed
WO-2001047939-A1 HETEROCYCLIC METALLOCENE COMPOUNDS AND USE THEREOF IN CATALYST SYSTEMS FOR PRODUCING OLEFIN POLYMERS BASELL TECHNOLOGY COMPANY B.V. (NL) 2001-07-05 WO disclosed
WO-2001048039-A2 PROCESS FOR THE PREPARATION OF ETHYLENE POLYMERS BASELL TECHNOLOGY COMPANY B.V. (NL) 2001-07-05 WO disclosed