Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.50 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.50 |
| ▸ | INPPL1 | O15357 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | TTK | P33981 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PI4KA | P42356 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 2/20 | 0.37 |
| ▸ | MST1R | Q04912 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 4/20 | 0.37 |
| ▸ | CDK8 | P49336 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18228546 | 1.00 | MKNK1 (0.50) | MKNK1MKNK2INPPL1CYP11B2DYRK1A | |
| SCHEMBL13086621 | 0.87 | MKNK1 (0.49) | MKNK1MKNK2INPPL1CYP11B2DYRK1A | |
| SCHEMBL20186871 | 0.79 | PFKFB3 (0.52) | DYRK1APIK3CDPIK3CAPIK3CBPI4KA | |
| Hydrochloric Acid SCHEMBL30806069 | 0.79 | PFKFB3 (0.41) | MKNK1MKNK2AURKATTKAURKB | |
| SCHEMBL18228215 | 0.79 | PFKFB3 (0.52) | DYRK1APIK3CDPIK3CAPIK3CBPI4KA | |
| SCHEMBL31456988 | 0.79 | PFKFB3 (0.52) | DYRK1APIK3CDPIK3CAPIK3CBPI4KA | |
| SCHEMBL19604964 | 0.78 | GPR55 (0.48) | MKNK1MKNK2DYRK1AAURKATTK | |
| SCHEMBL16089005 | 0.78 | GPR55 (0.48) | MKNK1MKNK2DYRK1AAURKATTK | |
| SCHEMBL12453539 | 0.78 | GPR55 (0.48) | MKNK1MKNK2DYRK1AAURKATTK | |
| SCHEMBL12304985 | 0.77 | MKNK1 (0.41) | MKNK1MKNK2INPPL1CYP11B2DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180148429-A1 | SUBSTITUTED QUINOXALINE DERIVATIVES | SELVITA S.A. (PL) | 2018-05-31 | — | — | US | disclosed |
| US-20180148429-A1 | SUBSTITUTED QUINOXALINE DERIVATIVES | SELVITA S.A. (PL) | 2018-05-31 | — | — | US | disclosed |
| WO-2016180536-A1 | SUBSTITUTED QUINOXALINE DERIVATIVES | SELVITA S.A. (PL) | 2016-11-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180148429-A1 | SUBSTITUTED QUINOXALINE DERIVATIVES | BRCA1, NQO2, NQO1 | MKNK1 559/4885MKNK2 599/4885INPPL1 2904/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.