Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | PRKDC | P78527 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | G6PD | P11413 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15600855 | 0.86 | HTT (0.49) | HTTTDP1ALDH1A1L3MBTL1MAPT | |
| SCHEMBL10020888 | 0.85 | HTT (0.59) | HTTTDP1ALDH1A1L3MBTL1POLB | |
| SCHEMBL14785603 | 0.85 | ALDH1A1 (0.58) | HTTTDP1ALDH1A1L3MBTL1POLB | |
| SCHEMBL6376231 | 0.84 | HTT (0.58) | HTTTDP1ALDH1A1L3MBTL1POLB | |
| SCHEMBL8009996 | 0.84 | HTT (0.58) | HTTTDP1ALDH1A1L3MBTL1POLB | |
| SCHEMBL14782151 | 0.84 | ALDH1A1 (0.48) | HTTTDP1ALDH1A1L3MBTL1MAPT | |
| SCHEMBL14660718 | 0.83 | POLB (0.58) | HTTTDP1ALDH1A1L3MBTL1POLB | |
| SCHEMBL9073829 | 0.82 | HTT (0.56) | HTTTDP1ALDH1A1L3MBTL1POLB | |
| SCHEMBL30773453 | 0.81 | HTT (0.54) | HTTTDP1ALDH1A1L3MBTL1POLB | |
| SCHEMBL6677617 | 0.81 | HTT (0.54) | HTTTDP1ALDH1A1L3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016183278-A1 | HETEROARYL COMPOUNDS FOR KINASE INHIBITION | ARIAD PHARMACEUTICALS, INC. (US) | 2016-11-17 | — | — | WO | disclosed |