Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | APEX1 | P27695 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18240656 | 1.00 | LMNA (0.46) | LMNAAKR1C3KEAP1NFE2L2ALDH1A1 | |
| SCHEMBL18240573 | 0.95 | STAT3 (0.41) | LMNAAKR1C3ALDH1A1SMN1; SMN2CNR1 | |
| SCHEMBL18240574 | 0.95 | STAT3 (0.41) | LMNAAKR1C3ALDH1A1SMN1; SMN2CNR1 | |
| SCHEMBL1334629 | 0.91 | AKR1C3 (0.50) | LMNAAKR1C3APEX1KMT2ACES2 | |
| SCHEMBL1334624 | 0.91 | AKR1C3 (0.50) | LMNAAKR1C3APEX1KMT2ACES2 | |
| SCHEMBL18240604 | 0.89 | ACP3 (0.41) | LMNAAKR1C3KEAP1NFE2L2ALDH1A1 | |
| SCHEMBL18240605 | 0.89 | ACP3 (0.41) | LMNAAKR1C3KEAP1NFE2L2ALDH1A1 | |
| SCHEMBL18240602 | 0.89 | ACP3 (0.41) | LMNAAKR1C3KEAP1NFE2L2ALDH1A1 | |
| SCHEMBL18240784 | 0.87 | LMNA (0.43) | LMNANFE2L2ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL18240785 | 0.87 | LMNA (0.43) | LMNANFE2L2ALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2906970-B1 | HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS WITH REDUCED TACK | NOVARTIS AG (CH) | 2016-11-23 | — | — | EP | claimed |