Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 9/20 | 0.33 |
| ▸ | VNN1 | O95497 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20177980 | 0.81 | APLNR (0.38) | APLNRLMNA | |
| SCHEMBL18493105 | 0.79 | APLNR (0.33) | APLNR | |
| SCHEMBL20189120 | 0.75 | APLNR (0.37) | APLNRPOLBLMNA | |
| SCHEMBL20189117 | 0.75 | APLNR (0.37) | APLNRPOLBLMNA | |
| SCHEMBL28219965 | 0.74 | — | — | |
| SCHEMBL20166344 | 0.73 | APLNR (0.35) | APLNR | |
| SCHEMBL20168857 | 0.73 | APLNR (0.35) | APLNR | |
| SCHEMBL18245749 | 0.72 | APLNR (0.46) | APLNR | |
| SCHEMBL18493106 | 0.72 | APLNR (0.36) | APLNR | |
| SCHEMBL18247242 | 0.71 | APLNR (0.41) | APLNRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3300500-A1 | TRIAZOLE AGONISTS OF THE APJ RECEPTOR | Amgen Inc. (US) | 2018-04-04 | — | — | EP | disclosed |
| WO-2016187308-A1 | TRIAZOLE AGONISTS OF THE APJ RECEPTOR | AMGEN INC. (US) | 2016-11-24 | — | — | WO | disclosed |