Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18493106 | 0.83 | APLNR (0.36) | APLNR | |
| SCHEMBL20189117 | 0.83 | APLNR (0.37) | APLNRLMNACYP1A2CYP3A4HSD17B10 | |
| SCHEMBL20189120 | 0.83 | APLNR (0.37) | APLNRLMNACYP1A2CYP3A4HSD17B10 | |
| SCHEMBL18247334 | 0.81 | APLNR (0.33) | APLNRLMNA | |
| SCHEMBL18493105 | 0.80 | APLNR (0.33) | APLNR | |
| SCHEMBL18247242 | 0.79 | APLNR (0.41) | APLNRLMNACYP1A2CYP3A4HSD17B10 | |
| SCHEMBL21766929 | 0.79 | APLNR (0.51) | APLNR | |
| SCHEMBL21766928 | 0.79 | APLNR (0.51) | APLNR | |
| SCHEMBL20168857 | 0.77 | APLNR (0.35) | APLNR | |
| SCHEMBL20166344 | 0.77 | APLNR (0.35) | APLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018093577-A1 | CYCLOALKYL SUBSTITUTED TRIAZOLE COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC. (US) | 2018-05-24 | — | — | WO | disclosed |