Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | FAAH | O00519 | 4/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18459793 | 0.87 | POLB (0.43) | OPRK1POLBMAPTRAB9AFAAH | |
| SCHEMBL4400107 | 0.85 | POLB (0.43) | OPRK1POLBMAPTRAB9AMCHR1 | |
| SCHEMBL14968453 | 0.85 | POLB (0.46) | OPRK1POLBMAPTRAB9AMCHR1 | |
| SCHEMBL13892196 | 0.84 | POLB (0.49) | POLBMAPTRAB9AMCHR1HDAC3 | |
| SCHEMBL18459792 | 0.84 | POLB (0.49) | OPRK1POLBMAPTRAB9AMCHR1 | |
| SCHEMBL18249449 | 0.81 | POLB (0.49) | OPRK1POLBMAPTRAB9AHDAC3 | |
| SCHEMBL4397929 | 0.80 | POLB (0.40) | OPRK1POLBMAPTMCHR1HDAC3 | |
| SCHEMBL18762637 | 0.80 | POLB (0.41) | OPRK1POLBMAPTRAB9AMCHR1 | |
| SCHEMBL13643855 | 0.80 | OPRK1 (0.41) | OPRK1POLBMAPTRAB9AHDAC3 | |
| SCHEMBL13643867 | 0.78 | OPRK1 (0.44) | OPRK1POLBMAPTFAAHHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016187558-A2 | METHOD TO IMPROVE NEUROLOGIC OUTCOMES IN TEMPERATURE MANAGED PATIENTS | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2016-11-24 | — | — | WO | disclosed |