SCHEMBL18249461

SCHEMBL18249461

CCOC(=O)N(CC)c1cccc(C)c1OC(=O)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 8/20 0.45
ALDH1A1 P00352 4/20 0.45
LMNA P02545 3/20 0.45
TSHR P16473 1/20 0.44
CYP3A4 P08684 2/20 0.40
SMN1; SMN2 Q16637 3/20 0.40
PKM P14618 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
GAA P10253 2/20 0.39
RAB9A P51151 2/20 0.39
NPC1 O15118 1/20 0.39
MEN1 O00255 3/20 0.39
NOD2 Q9HC29 1/20 0.39
KDM4E B2RXH2 1/20 0.39
HSP90AA1 P07900 1/20 0.39
MAPT P10636 1/20 0.39
HPGD P15428 1/20 0.39
MAPK1 P28482 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20164202 0.89 KMT2A (0.41) KMT2AALDH1A1TSHRSMN1; SMN2GAA
SCHEMBL20164292 0.88 THRB (0.38) KMT2AALDH1A1LMNATSHRCYP3A4
SCHEMBL18249382 0.87 KMT2A (0.45) KMT2AALDH1A1LMNATSHRSMN1; SMN2
SCHEMBL20164285 0.87 TP53 (0.44) KMT2AALDH1A1LMNATSHRPKM
SCHEMBL18249481 0.86 KMT2A (0.43) KMT2AALDH1A1LMNATSHRSMN1; SMN2
SCHEMBL18249465 0.84 KMT2A (0.45) KMT2AALDH1A1LMNASMN1; SMN2PKM
SCHEMBL18249419 0.84 KDM4E (0.48) KMT2AALDH1A1LMNATSHRCYP3A4
SCHEMBL20164273 0.83 MAPT (0.43) KMT2AALDH1A1LMNATSHRSMN1; SMN2
SCHEMBL18249478 0.81 TSHR (0.41) KMT2AALDH1A1LMNATSHRCYP3A4
SCHEMBL18249412 0.77 MAPT (0.37) KMT2AALDH1A1LMNATSHRSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3298048-B1 CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS BASELL POLIOLEFINE ITALIA SRL (IT) 2019-07-03 EP disclosed
US-10221256-B2 Catalyst components for the polymerization of olefins BASELL POLIOLEFINE ITALIA S.R.L. (IT) 2019-03-05 US disclosed
US-20180142044-A1 CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS BASELL POLIOLEFINE ITALIA S.R.L. (IT) 2018-05-24 US disclosed
EP-3298048-A1 CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS Basell Poliolefine Italia S.r.l. (IT) 2018-03-28 EP disclosed
WO-2016184884-A1 CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS BASELL POLIOLEFINE ITALIA S.R.L. (IT) 2016-11-24 WO disclosed