Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glutamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A3 | P43003 | 5/20 | 0.64 |
| ▸ | SLC1A2 | P43004 | 5/20 | 0.64 |
| ▸ | SLC1A1 | P43005 | 4/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | GRM8 | O00222 | 2/20 | 0.64 |
| ▸ | GRM6 | O15303 | 2/20 | 0.64 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.64 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.64 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.64 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.64 |
| ▸ | GSR | P00390 | 2/20 | 0.64 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.64 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.64 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.64 |
| ▸ | GRM5 | P41594 | 1/20 | 0.64 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.64 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.64 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.64 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.64 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| D-Glutamate SCHEMBL21410037 | 1.00 | SLC1A3 (0.64) | SLC1A3SLC1A2SLC1A1CYP1A2GRM8 | |
| D-Glutamate SCHEMBL28525856 | 1.00 | SLC1A3 (0.64) | SLC1A3SLC1A2SLC1A1CYP1A2GRM8 | |
| Glutamic Acid SCHEMBL6130437 | 0.94 | SLC1A3 (0.72) | SLC1A3SLC1A2SLC1A1CYP1A2GRM8 | |
| Glutamic Acid SCHEMBL24357 | 0.94 | SLC1A3 (0.72) | SLC1A3SLC1A2SLC1A1CYP1A2GRM8 | |
| Glutamic Acid SCHEMBL1126187 | 0.94 | SLC1A3 (0.72) | SLC1A3SLC1A2SLC1A1CYP1A2GRM8 | |
| D-Glutamate SCHEMBL3512077 | 0.94 | SLC1A3 (0.72) | SLC1A3SLC1A2SLC1A1CYP1A2GRM8 | |
| Glutamic Acid SCHEMBL5614072 | 0.94 | SLC1A3 (0.72) | SLC1A3SLC1A2SLC1A1CYP1A2GRM8 | |
| D-Glutamate SCHEMBL9176409 | 0.94 | SLC1A3 (0.72) | SLC1A3SLC1A2SLC1A1CYP1A2GRM8 | |
| D-Glutamate SCHEMBL28407836 | 0.92 | SLC1A3 (0.55) | SLC1A3SLC1A2SLC1A1CYP1A2GRM8 | |
| D-Glutamate SCHEMBL19876607 | 0.91 | SLC1A3 (0.67) | SLC1A3SLC1A2SLC1A1CYP1A2GRM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11753661-B2 | Process for the biological production of methacrylic acid and derivatives thereof | Mitsubishi Chemical UK Limited (GB) | 2023-09-12 | — | — | US | disclosed |
| US-11753660-B2 | Process for the biological production of methacrylic acid and derivatives thereof | Mitsubishi Chemical UK Limited (GB) | 2023-09-12 | — | — | US | disclosed |
| US-20220372527-A1 | PROCESS FOR THE BIOLOGICAL PRODUCTION OF METHACRYLIC ACID AND DERIVATIVES THEREOF | Mitsubishi Chemical UK Limited (GB) | 2022-11-24 | — | — | US | disclosed |
| US-20220204999-A1 | PROCESS FOR THE BIOLOGICAL PRODUCTION OF METHACRYLIC ACID AND DERIVATIVES THEREOF | Mitsubishi Chemical UK Limited (GB) | 2022-06-30 | — | — | US | disclosed |
| US-11248243-B2 | Process for the biological production of methacrylic acid and derivatives thereof | Mitsubishi Chemical UK Limited (GB) | 2022-02-15 | — | — | US | disclosed |
| US-20200308609-A1 | PROCESS FOR THE BIOLOGICAL PRODUCTION OF METHACRYLIC ACID AND DERIVATIVES THEREOF | Mitsubishi Chemical UK Limited (GB) | 2020-10-01 | — | — | US | disclosed |
| US-10724058-B2 | Process for the biological production of methacrylic acid and derivatives thereof | LUCITE INTERNATIONAL UK LIMITED (GB) | 2020-07-28 | — | — | US | disclosed |
| US-10704063-B2 | Process for the biological production of methacrylic acid and derivatives thereof | LUCITE INTERNATIONAL UK LIMITED (GB) | 2020-07-07 | — | — | US | disclosed |
| US-20180195095-A1 | PROCESS FOR THE BIOLOGICAL PRODUCTION OF METHACRYLIC ACID AND DERIVATIVES THEREOF | Mitsubishi Chemical UK Limited (GB) | 2018-07-12 | — | — | US | disclosed |
| US-20180171368-A1 | PROCESS FOR THE BIOLOGICAL PRODUCTION OF METHACRYLIC ACID AND DERIVATIVES THEREOF | Mitsubishi Chemical UK Limited (GB) | 2018-06-21 | — | — | US | disclosed |
| EP-3298153-A1 | PROCESS FOR THE BIOLOGICAL PRODUCTION OF METHACRYLIC ACID AND DERIVATIVES THEREOF | Lucite International UK Limited (GB) | 2018-03-28 | — | — | EP | disclosed |
| WO-2016185211-A1 | PROCESS FOR THE BIOLOGICAL PRODUCTIION OF METHACRYLIC ACID AND DERIVATIVES THEREOF | LUCITE INTERNATIONAL UK LIMITED (GB) | 2016-11-24 | — | — | WO | disclosed |