Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18257581 | 0.90 | IDO1 (0.38) | BRD9IDO1TDP2BRD4HSP90AA1 | |
| SCHEMBL18257531 | 0.85 | TTK (0.38) | BRD9IDO1TDP2BRD4HSP90AA1 | |
| SCHEMBL16748917 | 0.80 | TDP2 (0.42) | BRD9IDO1TDP2BRD4HSP90AA1 | |
| SCHEMBL30619395 | 0.73 | NR1H4 (0.58) | BRD9RXFP1LMNAPOLB | |
| SCHEMBL1162987 | 0.73 | NR1H4 (0.58) | BRD9RXFP1LMNAPOLB | |
| SCHEMBL28444082 | 0.73 | CHRM3 (0.52) | BRD9LMNAMEN1KMT2A | |
| SCHEMBL4414634 | 0.72 | LMNA (0.48) | BRD9IDO1BRD4HSP90AA1HSP90AB1 | |
| SCHEMBL404007 | 0.71 | TDP2 (0.42) | BRD9IDO1TDP2BRD4HSP90AA1 | |
| SCHEMBL3783723 | 0.71 | BRD9 (0.47) | BRD9IDO1BRD4HSP90AA1HSP90AB1 | |
| Acetic Acid SCHEMBL1157172 | 0.71 | CHRM3 (0.50) | BRD9LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2864336-B1 | BENZO[B]ISOXAZOLOAZEPINE BROMODOMAIN INHIBITORS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS INC (US) | 2016-11-23 | — | — | EP | disclosed |