Citric Acid

Citric Acid

SCHEMBL182591

Cl.O=C(O)CC(O)(CC(=O)O)C(=O)O.[NaH]

nearest known ligand 0.88

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2

The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 1/20 0.40
ALDH1A1 P00352 2/20 0.88
HMGCR P04035 1/20 0.46
CHRM1 P11229 1/20 0.46
TBXA2R P21731 1/20 0.46
ADRA1A P35348 1/20 0.46
TSHR P16473 2/20 0.43
CYP2D6 P10635 2/20 0.43
CYP2C19 P33261 1/20 0.43
HIF1A Q16665 1/20 0.43
ACLY P53396 4/20 0.42
KDM4E B2RXH2 3/20 0.42
LMNA P02545 2/20 0.42
MAPT P10636 1/20 0.42
ALOX15 P16050 1/20 0.42
SLC13A5 Q86YT5 4/20 0.41
CPT2 P23786 1/20 0.41
CYP1A2 P05177 1/20 0.40
KMT2A Q03164 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Citric Acid SCHEMBL182589 1.00 ALDH1A1 (0.88) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL212320 1.00 ALDH1A1 (0.88) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL9838279 1.00 ALDH1A1 (0.88) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL5930978 0.97 ALDH1A1 (0.83) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL182590 0.97 ALDH1A1 (0.83) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL17627562 0.97 ALDH1A1 (0.83) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL28706585 0.97 ALDH1A1 (0.83) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL1462474 0.97 ALDH1A1 (0.83) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL7369132 0.97 ALDH1A1 (0.83) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL4818293 0.97 ALDH1A1 (0.83) ALDH1A1HMGCRCHRM1TBXA2RADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 525 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113874318-B Method for obtaining mesoporous silica particle-supported metal oxides 柏林工业大学 2024-05-07 CN claimed
CN-111683901-B Method for obtaining mesoporous silica particles with surface functionalization 柏林工业大学 2024-03-26 CN claimed
CN-113425835-B Growth hormone crude drug solution, water injection and preparation method thereof 常州健益生物制药有限公司 2024-03-19 CN claimed
CN-115786454-A Nucleic acid sample preservation reagent and application thereof 杭州安旭生物科技股份有限公司 2023-03-14 CN claimed
US-11389785-B2 Method for obtaining mesoporous silica particles with surface functionalization Technische Universität Berlin (DE) 2022-07-19 US claimed
US-20220161240-A1 METHOD FOR OBTAINING METAL OXIDES SUPPORTED ON MESOPOROUS SILICA PARTICLES Technische Universität Berlin (DE) 2022-05-26 US claimed
CN-113874318-A Method for obtaining mesoporous silica particle-supported metal oxide 柏林工业大学 2021-12-31 CN claimed
CN-113425835-A Growth hormone raw material medicine solution, water injection and preparation method thereof 常州健益生物制药有限公司 2021-09-24 CN claimed
CN-110407957-B Beta-cyclodextrin derivative and preparation method thereof, and preparation method and application of beta-cyclodextrin derivative-gold nanocomposite 西安文理学院 2021-09-14 CN claimed
US-20210031172-A1 METHOD FOR OBTAINING MESOPOROUS SILICA PARTICLES WITH SURFACE FUNCTIONALIZATION Technische Universität Berlin (DE) 2021-02-04 US claimed
WO-2011095296-A1 EPOXIDATION PROCESS MOMENTIVE SPECIALTY CHEMICALS RESEARCH S.A. (BE) 2011-08-11 WO claimed
EP-2354129-A1 Epoxidation process Momentive Specialty Chemicals Research Belgium S.A. (BE) 2011-08-10 EP claimed
US-20110081416-A1 ORDERED MESOPOROUS SILICA MATERIAL FORMAC PHARMACEUTICALS N.V. (BE) 2011-04-07 US claimed
EP-2282973-A2 ORDERED MESOPOROUS SILICA MATERIAL Formac Pharmaceuticals N.v. (BE) 2011-02-16 EP claimed
WO-2009133100-A2 ORDERED MESOPOROUS SILICA MATERIAL FORMAC PHARMACEUTICALS N.V. (BE) 2009-11-05 WO claimed
US-7355029-B2 Genes encoding carbon metabolism and energy-producing proteins BASF AG (DE) 2008-04-08 US claimed
CN-101122562-A Oligonucleotide chip for detecting transplanted kidney function and its uses UNIV ZHEJIANG (CN) 2008-02-13 CN claimed
US-6037173-A NUCLEIC ACID MOLECULE THAT CODES A THYROID RECEPTOR BINDING PROTEIN; FOR DIAGNOSIS AND TREATMENT OF DISEASES ASSOCIATED WITH DEFECTS IN THE FUNCTION OF THYROID BINDING PROTEIN; FOR DETECTION OF MUDULATORS OF PROTEIN FUNCTION MILLENNIUM PHARMACEUTICALS, INC. (US) 2000-03-14 US claimed
US-5466781-A Isolation of bodies, suspension, agitation and centrifuging CHIRON THERAPEUTICS (US) 1995-11-14 US claimed
US-4404132-A FREE OF THROMBIN, HEPARIN, THROMBOPLASTIN ACTIVITY CUTTER LABORATORIES, INC. (US) 1983-09-13 US claimed