Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.50 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.48 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.46 |
| ▸ | FEN1 | P39748 | 2/20 | 0.46 |
| ▸ | ATR | Q13535 | 2/20 | 0.44 |
| ▸ | PRKDC | P78527 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | USP7 | Q93009 | 4/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 2/20 | 0.40 |
| ▸ | AR | P10275 | 2/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18263119 | 0.82 | IL4 (0.43) | GABRG2GABRB3GABRA5GABRA3ALOX5AP | |
| SCHEMBL6169284 | 0.78 | FEN1 (0.57) | ESR2GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL18263117 | 0.76 | LCK (0.47) | ALOX5APFEN1ATRPRKDCUSP7 | |
| SCHEMBL18263139 | 0.76 | FEN1 (0.47) | ALOX5APFEN1USP7CYP11B1CYP11B2 | |
| SCHEMBL5845273 | 0.76 | ESR2 (0.59) | ESR2GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL488494 | 0.73 | USP7 (0.62) | USP7ALDH1A1 | |
| SCHEMBL18263158 | 0.73 | EGLN1 (0.54) | GABRG2GABRB3GABRA5GABRA3ATR | |
| SCHEMBL14231513 | 0.71 | ESR2 (0.56) | ESR2GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7709223 | 0.70 | ESR2 (0.50) | ESR2GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL17436061 | 0.70 | ESR2 (0.50) | ESR2GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3145935-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS DAG-LIPASE INHIBITORS | Universiteit Leiden (NL) | 2017-03-29 | — | — | EP | disclosed |
| WO-2016188972-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS DAG-LIPASE INHIBITORS | UNIVERSITEIT LEIDEN (NL) | 2016-12-01 | — | — | WO | disclosed |
| WO-2016188972-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS DAG-LIPASE INHIBITORS | UNIVERSITEIT LEIDEN (NL) | 2016-12-01 | — | — | WO | disclosed |