Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.58 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.49 |
| ▸ | FEN1 | P39748 | 2/20 | 0.49 |
| ▸ | KIF11 | P52732 | 6/20 | 0.48 |
| ▸ | CLK1 | P49759 | 1/20 | 0.48 |
| ▸ | USP7 | Q93009 | 3/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.45 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.45 |
| ▸ | COMT | P21964 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL312412 | 0.81 | MAP4K4 (0.56) | MAP4K4KIF11CLK1KCNH2PIK3CA | |
| SCHEMBL18263141 | 0.81 | FYN (0.57) | MAP4K4CLK1USP7 | |
| SCHEMBL1348639 | 0.80 | MAP4K4 (0.55) | MAP4K4ALOX5APFEN1KIF11CLK1 | |
| SCHEMBL313311 | 0.80 | MAP4K4 (0.55) | MAP4K4KIF11CLK1KCNH2PIK3CA | |
| SCHEMBL18615823 | 0.78 | MAP4K4 (0.60) | MAP4K4KIF11CLK1KCNH2 | |
| SCHEMBL17027113 | 0.78 | ALDH1A1 (0.45) | MAP4K4ALOX5APFEN1USP7 | |
| SCHEMBL31202649 | 0.78 | ALDH1A1 (0.45) | MAP4K4ALOX5APFEN1USP7 | |
| SCHEMBL18263118 | 0.77 | MAP4K4 (0.58) | MAP4K4USP7KCNH2MINK1 | |
| SCHEMBL18240070 | 0.77 | FYN (0.58) | MAP4K4CLK1USP7 | |
| SCHEMBL488494 | 0.77 | USP7 (0.62) | MAP4K4USP7CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3145935-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS DAG-LIPASE INHIBITORS | Universiteit Leiden (NL) | 2017-03-29 | — | — | EP | disclosed |
| WO-2016188972-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS DAG-LIPASE INHIBITORS | UNIVERSITEIT LEIDEN (NL) | 2016-12-01 | — | — | WO | disclosed |
| WO-2016188972-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS DAG-LIPASE INHIBITORS | UNIVERSITEIT LEIDEN (NL) | 2016-12-01 | — | — | WO | disclosed |