SCHEMBL18263261

SCHEMBL18263261

O=C(OC12CC3CC(CC(C3)C1)C2)c1ccccc1NCc1cc(O)ccc1O

nearest known ligand 0.67

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CKS1B P61024 2/20 0.67
SKP2 Q13309 2/20 0.67
HSP90AA1 P07900 2/20 0.67
SKP1 P63208 1/20 0.67
EGFR P00533 14/20 0.52
CNR2 P34972 1/20 0.43
HKDC1 Q2TB90 1/20 0.41
RGS12 O14924 1/20 0.40
ALDH1A1 P00352 1/20 0.40
LCK P06239 1/20 0.40
MAPT P10636 1/20 0.40
CAMKK2 Q96RR4 1/20 0.40
NOX4 Q9NPH5 1/20 0.40
TDP1 Q9NUW8 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18263262 0.81 EGFR (0.47) CKS1BSKP2HSP90AA1SKP1EGFR
Adamantane SCHEMBL28227462 0.81 EGFR (0.55) CKS1BSKP2HSP90AA1SKP1EGFR
SCHEMBL29375858 0.81 HSP90AA1 (1.00) CKS1BSKP2HSP90AA1SKP1EGFR
SCHEMBL182500 0.81 HSP90AA1 (1.00) CKS1BSKP2HSP90AA1SKP1EGFR
SCHEMBL6259074 0.79 EGFR (0.66) HSP90AA1EGFRHKDC1NOX4
SCHEMBL6258501 0.75 EGFR (0.63) HSP90AA1EGFRRGS12ALDH1A1LCK
SCHEMBL31060627 0.75 EGFR (0.52) HSP90AA1EGFRHKDC1RGS12ALDH1A1
SCHEMBL6260824 0.75 EGFR (0.52) HSP90AA1EGFRHKDC1RGS12ALDH1A1
SCHEMBL31168812 0.74 CKS1B (0.64) CKS1BSKP2HSP90AA1SKP1EGFR
SCHEMBL3651340 0.74 CKS1B (0.64) CKS1BSKP2HSP90AA1SKP1EGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016190847-A1 SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE CALITOR SCIENCES, LLC (US) 2016-12-01 WO disclosed