Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | TLR4 | O00206 | 3/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.31 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.31 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.31 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18268208 | 0.91 | KDM4E (0.41) | CA2TLR4MAPTKDM4EALDH1A1 | |
| SCHEMBL18268191 | 0.90 | CA2 (0.41) | CA2TLR4ABCB1ABCG2CYP19A1 | |
| SCHEMBL18268184 | 0.83 | CA2 (0.42) | CA2MAPTLMNAKDM4EALDH1A1 | |
| SCHEMBL18268183 | 0.81 | CA2 (0.39) | CA2MAPTLMNAALDH1A1NPSR1 | |
| SCHEMBL18270510 | 0.81 | KDM4E (0.43) | CA2TLR4MAPTKDM4EALDH1A1 | |
| SCHEMBL18268180 | 0.77 | CA2 (0.44) | CA2ABCB1ABCG2MAPTCYP19A1 | |
| SCHEMBL18268188 | 0.74 | KDM4E (0.48) | CA2TLR4MAPTLMNAKDM4E | |
| SCHEMBL18268186 | 0.74 | KDM4E (0.48) | CA2TLR4MAPTLMNAKDM4E | |
| SCHEMBL18268202 | 0.74 | KDM4E (0.48) | CA2TLR4MAPTLMNAKDM4E | |
| SCHEMBL18268185 | 0.73 | ALDH1A1 (0.39) | CA2MAPTLMNAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834525-B2 | Inhibitors of paxillin function and related compositions and methods | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2017-12-05 | — | — | US | disclosed |
| US-20160347725-A1 | INHIBITORS OF PAXILLIN FUNCTION AND RELATED COMPOSITIONS AND METHODS | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION | 2016-12-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160347725-A1 | INHIBITORS OF PAXILLIN FUNCTION AND RELATED COMPOSITIONS AND METHODS | CTTN, PTK2, CDC42 | CA2 3158/4885TLR4 4639/4885ABCB1 3891/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.