Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Crizotinib. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET known ✓ | P08581 | 11/20 | 0.91 |
| ▸ | ALK known ✓ | Q9UM73 | 7/20 | 0.91 |
| ▸ | ROS1 known ✓ | P08922 | 2/20 | 0.91 |
| ▸ | MST1R known ✓ | Q04912 | 2/20 | 0.91 |
| ▸ | NPM1 known ✓ | P06748 | 1/20 | 0.91 |
| ▸ | EML4 known ✓ | Q9HC35 | 1/20 | 0.91 |
| ▸ | MAP4K3 | Q8IVH8 | 8/20 | 0.91 |
| ▸ | JAK2 | O60674 | 6/20 | 0.91 |
| ▸ | JAK3 | P52333 | 3/20 | 0.91 |
| ▸ | PLK4 | O00444 | 2/20 | 0.91 |
| ▸ | AURKA | O14965 | 2/20 | 0.91 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.91 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.91 |
| ▸ | ABL1 | P00519 | 2/20 | 0.91 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.91 |
| ▸ | INSR | P06213 | 2/20 | 0.91 |
| ▸ | LCK | P06239 | 2/20 | 0.91 |
| ▸ | FES | P07332 | 2/20 | 0.91 |
| ▸ | CSF1R | P07333 | 2/20 | 0.91 |
| ▸ | LYN | P07948 | 2/20 | 0.91 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL16324188 | 0.95 | MET (0.82) | METMAP4K3ALKJAK2JAK3 | |
| Crizotinib SCHEMBL29622387 | 0.95 | MET (1.00) | METMAP4K3ALKJAK2JAK3 | |
| Crizotinib SCHEMBL14811801 | 0.95 | MET (1.00) | METMAP4K3ALKJAK2JAK3 | |
| Crizotinib SCHEMBL94020 | 0.95 | MET (1.00) | METMAP4K3ALKJAK2JAK3 | |
| Crizotinib SCHEMBL30129754 | 0.95 | MET (1.00) | METMAP4K3ALKJAK2JAK3 | |
| Crizotinib SCHEMBL29351506 | 0.95 | MET (1.00) | METMAP4K3ALKJAK2JAK3 | |
| Crizotinib SCHEMBL28844303 | 0.95 | MET (1.00) | METMAP4K3ALKJAK2JAK3 | |
| Crizotinib SCHEMBL93829 | 0.95 | MET (1.00) | METMAP4K3ALKJAK2JAK3 | |
| Crizotinib SCHEMBL29831970 | 0.95 | MET (1.00) | METMAP4K3ALKJAK2JAK3 | |
| Crizotinib SCHEMBL28844302 | 0.95 | MET (1.00) | METMAP4K3ALKJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2315601-B1 | COMBINATION OF A C-MET ANTAGONIST AND AN AMINOHETEROARYL COMPOUND FOR THE TREATMENT OF CANCER | PF MEDICAMENT (FR) | 2018-02-14 | — | — | EP | disclosed |
| US-9375425-B2 | Combination of a C-Met antagonist and an aminoheteroaryl compound for the treatment of cancer | PIERRE FABRE MEDICAMENT (FR) | 2016-06-28 | — | — | US | disclosed |
| US-20150250780-A1 | COMBINATION OF A C-MET ANTAGONIST AND AN AMINOHETEROARYL COMPOUND FOR THE TREATMENT OF CANCER | PIERRE FABRE MEDICAMENT (FR) | 2015-09-10 | — | — | US | disclosed |
| US-9011865-B2 | Combination of a c-Met antagonist and an aminoheteroaryl compound for the treatment of cancer | Pierre Gabre Medicament (FR) | 2015-04-21 | — | — | US | disclosed |
| US-20140288086-A1 | ENANTIOMERICALLY PURE AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS | PFIZER INC. (US) | 2014-09-25 | — | — | US | disclosed |
| US-8785632-B2 | Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors | AGOURON PHARMACEUTICALS, INC. (US) | 2014-07-22 | — | — | US | disclosed |
| US-20140186356-A1 | COMBINATION OF A C-MET ANTAGONIST AND AN AMINOHETEROARYL COMPOUND FOR THE TREATMENT OF CANCER | PIERRE FABRE MEDICAMENT (FR) | 2014-07-03 | — | — | US | disclosed |
| US-8623359-B2 | Combination of a c-Met antagonist and an aminoheteroaryl compound for the treatment of cancer | PIERRE FABRE MEDICAMENT (FR) | 2014-01-07 | — | — | US | disclosed |
| EP-1786785-B9 | ENANTIOMERICALLY PURE AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS | PFIZER (US) | 2013-05-22 | — | — | EP | disclosed |
| US-20120263706-A1 | ENANTIOMERICALLY PURE AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS | AGOURON PHARMACEUTICALS, INC. | 2012-10-18 | — | — | US | disclosed |
| US-20110117098-A1 | COMBINATION OF A C-MET ANTAGONIST AND AN AMINOHETEROARYL COMPOUND FOR THE TREATMENT OF CANCER | PIERRE FABRE MEDICAMENT (FR) | 2011-05-19 | — | — | US | disclosed |
| EP-2315601-A1 | COMBINATION OF A C-MET ANTAGONIST AND AN AMINOHETEROARYL COMPOUND FOR THE TREATMENT OF CANCER | Pierre Fabre Médicament (FR) | 2011-05-04 | — | — | EP | disclosed |
| US-7858643-B2 | Crizotinib, a c-Met protein kinase inhibitor anticancer agent; 3-[(R)-1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine is crizotinib | AGOURON PHARMACEUTICALS, INC. (US) | 2010-12-28 | — | — | US | disclosed |
| US-20100324061-A1 | including crizotinib which is 3-[(R)-1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine; c-met inhibitors; hepatocyte growth factor (HGF) receptor (c-MET) receptor tyrosine kinase (RTK) | AGOURON PHARMACEUTICALS, INC. | 2010-12-23 | — | — | US | disclosed |
| EP-1784396-B1 | PYRAZOLE-SUBSTITUTED AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS | PFIZER (US) | 2010-12-22 | — | — | EP | disclosed |
| EP-1786785-B1 | ENANTIOMERICALLY PURE AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS | PFIZER (US) | 2010-04-07 | — | — | EP | disclosed |
| WO-2010003992-A1 | COMBINATION OF A C-MET ANTAGONIST AND AN AMINOHETEROARYL COMPOUND FOR THE TREATMENT OF CANCER | PIERRE FABRE MEDICAMENT (FR) | 2010-01-14 | — | — | WO | disclosed |
| EP-2143441-A1 | Combination of a c-Met antagonist and an aminoheteroaryl compound for the treatment of cancer | Pierre Fabre Medicament (FR) | 2010-01-13 | — | — | EP | disclosed |
| US-20060128724-A1 | Pyrazole-substituted aminoheteroaryl compounds as protein kinase inhibitors | AGOURON PHARMACEUTICALS, INC. | 2006-06-15 | — | — | US | disclosed |
| US-20060046991-A1 | Crizotinib, a c-Met protein kinase inhibitor anticancer agent; 3-[(R)-1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine is crizotinib | AGOURON PHARMACEUTICALS, INC. | 2006-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110117098-A1 | COMBINATION OF A C-MET ANTAGONIST AND AN AMINOHETEROARYL COMPOUND FOR THE TREATMENT OF CANCER | MET, HGF, EGFR | MET 1/4885ALK 26/4885ROS1 2043/4885 |
| US-20060128724-A1 | Pyrazole-substituted aminoheteroaryl compounds as protein kinase inhibitors | MET, MAP3K15, MAP3K19 | MET 1/4885ALK 136/4885ROS1 52/4885 |
| US-20060046991-A1 | Crizotinib, a c-Met protein kinase inhibitor anticancer agent; 3-[(R)-1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine is crizotinib | ALK, MET, ERBB2 | MET 2/4885ALK 1/4885ROS1 5/4885 |
| US-20100324061-A1 | including crizotinib which is 3-[(R)-1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine; c-met inhibitors; hepatocyte growth factor (HGF) receptor (c-MET) receptor tyrosine kinase (RTK) | MET, HGF, ALK | MET 1/4885ALK 3/4885ROS1 20/4885 |
| US-20120263706-A1 | ENANTIOMERICALLY PURE AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS | MET, MAP3K15, MAP3K1 | MET 1/4885ALK 190/4885ROS1 199/4885 |
| US-20150250780-A1 | COMBINATION OF A C-MET ANTAGONIST AND AN AMINOHETEROARYL COMPOUND FOR THE TREATMENT OF CANCER | MET, HGF, EGFR | MET 1/4885ALK 26/4885ROS1 2043/4885 |
| US-20140186356-A1 | COMBINATION OF A C-MET ANTAGONIST AND AN AMINOHETEROARYL COMPOUND FOR THE TREATMENT OF CANCER | MET, HGF, EGFR | MET 1/4885ALK 26/4885ROS1 2043/4885 |
| US-20140288086-A1 | ENANTIOMERICALLY PURE AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS | MET, MAP3K15, MAP3K1 | MET 1/4885ALK 190/4885ROS1 199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.