Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | SRD5A2 | P31213 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA3 | P07451 | 1/20 | 0.44 |
| ▸ | TYR | P14679 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8433248 | 0.94 | SRD5A2 (0.59) | HPGDNPSR1MCOLN3TSHRTP53 | |
| SCHEMBL458409 | 0.84 | NPSR1 (0.59) | HPGDNPSR1MCOLN3TSHRALDH1A1 | |
| SCHEMBL12988880 | 0.83 | NPSR1 (0.66) | HPGDNPSR1MCOLN3TSHRTP53 | |
| SCHEMBL2921303 | 0.83 | HPGD (0.56) | HPGDNPSR1MCOLN3ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL31125741 | 0.83 | NPSR1 (0.57) | HPGDNPSR1MCOLN3TSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL3759428 | 0.83 | NPSR1 (0.57) | HPGDNPSR1MCOLN3TSHRALDH1A1 | |
| SCHEMBL30268201 | 0.82 | NPSR1 (0.66) | HPGDNPSR1MCOLN3TSHRSRD5A2 | |
| SCHEMBL2462624 | 0.81 | NPSR1 (0.54) | HPGDNPSR1MCOLN3TSHRKMT2A | |
| SCHEMBL8035994 | 0.81 | NPSR1 (0.54) | HPGDNPSR1MCOLN3KMT2AALDH1A1 | |
| SCHEMBL4102311 | 0.81 | NPSR1 (0.60) | HPGDNPSR1MCOLN3KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324404-B2 | 3-thia-10-aza-phenanthrene derivatives | NYCOMED GMBH (DE) | 2012-12-04 | — | — | US | disclosed |
| EP-1797098-B1 | 3-OXA-10-AZA-PHENANTHRENES AS PDE4 OR PDE3/4 INHIBITORS | NYCOMED GMBH (DE) | 2011-05-04 | — | — | EP | disclosed |
| US-7838521-B2 | 3-oxa-10-aza-phenanthrenes | NYCOMED GMBH (DE) | 2010-11-23 | — | — | US | disclosed |
| US-20090239895-A1 | Novel 3-thia-10-aza-phenanthrene derivatives | NYCOMED GMBH (DE) | 2009-09-24 | — | — | US | disclosed |
| US-7589205-B2 | phosphodiesterase inhibitor; antiinflammatory agent; 3-thia-10-aza-phenanthrenes and iintermediates 3-(3,4-dialkoxy-phenyl)-tetrahydro-thiopyran-4-one and 3-(3,4-dialkoxy-phenyl)-1,1-dioxo-hexahydro-1-thiopyran-4-ylamine, useful for its preparation | NYCOMED GMBH (DE) | 2009-09-15 | — | — | US | disclosed |
| US-20080103168-A1 | Novel 3-Thia-10-Aza-Phenanthrene Derivatives | ATLANA PHARMA AG (DE) | 2008-05-01 | — | — | US | disclosed |
| US-20070259868-A1 | Novel 3-Oxa-10-Aza-Phenanthrenes | ALTANA PHARMA AG (DE) | 2007-11-08 | — | — | US | disclosed |
| EP-1797098-A2 | 3-OXA-10-AZA-PHENANTHRENES AS PDE4 OR PDE3/4 INHIBITORS | Altana Pharma AG (DE) | 2007-06-20 | — | — | EP | disclosed |
| EP-1791847-A2 | NOVEL 3-THIA-10-AZA-PHENANTHRENE DERIVATIVES | Altana Pharma AG (DE) | 2007-06-06 | — | — | EP | disclosed |
| WO-2006027345-A2 | NOVEL 3-THIA-10-AZA-PHENANTHRENE DERIVATIVES | ALTANA PHARMA AG (DE) | 2006-03-16 | — | — | WO | disclosed |
| WO-2006027344-A2 | 3-OXA-10-AZA-PHENANTHRENES AS PDE4 OR PDE3/4 INHIBITORS | ALTANA PHARMA AG (DE) | 2006-03-16 | — | — | WO | disclosed |
| EP-1075477-B1 | Novel Benzonaphthyridine-N-oxides | ALTANA PHARMA AG (DE) | 2003-03-12 | — | — | EP | disclosed |
| US-6306869-B1 | N-oxides | BYK GULDEN LOMBERG CHEMISCHE FEBRIK GMBH (DE) | 2001-10-23 | — | — | US | disclosed |
| EP-1075477-A1 | NOVEL N-OXIDES | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2001-02-14 | — | — | EP | disclosed |
| WO-1999057118-A1 | NOVEL N-OXIDES | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1999-11-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080103168-A1 | Novel 3-Thia-10-Aza-Phenanthrene Derivatives | PDE4A, PDE4B, PDE3A | HPGD 572/4885NPSR1 1546/4885MCOLN3 4415/4885 |
| US-20070259868-A1 | Novel 3-Oxa-10-Aza-Phenanthrenes | PDE4A, PDE4B, PDE3A | HPGD 513/4885NPSR1 1149/4885MCOLN3 4121/4885 |
| US-20090239895-A1 | Novel 3-thia-10-aza-phenanthrene derivatives | PDE4A, PDE4B, PDE3A | HPGD 572/4885NPSR1 1546/4885MCOLN3 4415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.