Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2882577 | 0.83 | NPSR1 (0.54) | NPSR1HPGDMCOLN3LMNAMAPT | |
| SCHEMBL25870885 | 0.83 | HPGD (0.54) | NPSR1HPGDMCOLN3LMNAMAPT | |
| SCHEMBL11936010 | 0.82 | CA1 (0.46) | NPSR1HPGDMCOLN3LMNAMAPT | |
| SCHEMBL12988880 | 0.81 | NPSR1 (0.66) | NPSR1HPGDMCOLN3LMNAMAPT | |
| SCHEMBL1827276 | 0.81 | HPGD (0.56) | NPSR1HPGDMCOLN3LMNAMAPT | |
| SCHEMBL2921303 | 0.81 | HPGD (0.56) | NPSR1HPGDMCOLN3LMNAMAPT | |
| SCHEMBL1825385 | 0.79 | HPGD (0.54) | NPSR1HPGDMCOLN3LMNAMAPT | |
| SCHEMBL4102311 | 0.79 | NPSR1 (0.60) | NPSR1HPGDMCOLN3LMNAMAPT | |
| SCHEMBL2462624 | 0.79 | NPSR1 (0.54) | NPSR1HPGDMCOLN3LMNAMAPT | |
| SCHEMBL12482771 | 0.79 | HPGD (0.54) | NPSR1HPGDMCOLN3LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2014285-A1 | NPYY5 antagonists | Shionogi&Co., Ltd. (JP) | 2009-01-14 | — | — | EP | disclosed |
| US-6156772-A | INDOLE HORMONE INHIBITORS | MERCK & CO., INC. (US) | 2000-12-05 | — | — | US | disclosed |
| WO-2000069433-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO., INC. (US) | 2000-11-23 | — | — | WO | disclosed |
| US-6077858-A | ADMINISTERING A SUBSTITUTED INDOLE COMPOUND TO THE PATIENTS FOR THE TREATMENT OF A VARIETY OF SEX-HORMONE RELATED AND OTHER CONDITIONS IN BOTH MEN AND WOMEN | MERCK & CO., INC. (US) | 2000-06-20 | — | — | US | disclosed |
| US-6004984-A | Antagonists of gonadotropin releasing hormone | MERCK & CO., INC. (US) | 1999-12-21 | — | — | US | disclosed |
| US-5985901-A | TREATMENT OF A VARIETY OF SEX-HORMONE RELATED AND OTHER CONDITIONS IN BOTH MEN AND WOMEN | MERCK & CO., INC. (US) | 1999-11-16 | — | — | US | disclosed |
| US-5981550-A | USEFUL IN TREATING A VARIETY OF SEX-HORMONE RELATED CONDITIONS IN BOTH MEN AND WOMEN, INCLUDING ENDOMETRIOSIS, UTERINE FIBROIDS, POLYCYSTIC OVARIAN DISEASE, HIRSUTISM, PRECOCIOUS PUBERTY, GONADAL STEROID-DEPENDENT NEOPLASIAS | MERCK & CO., INC. (US) | 1999-11-09 | — | — | US | disclosed |
| US-5756507-A | TREATING SEX HORMONE RELATED DISORDERS | MERCK & CO., INC. (US) | 1998-05-26 | — | — | US | disclosed |