Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL346759 | 0.79 | KDM4E (0.53) | KDM4EGAAALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL3649875 | 0.75 | CHRM3 (0.67) | SMN1; SMN2 | |
| SCHEMBL21207000 | 0.74 | ALDH1A1 (0.58) | KDM4EGAAALDH1A1NPSR1HPGD | |
| SCHEMBL21043976 | 0.70 | HTT (0.60) | KDM4EGAAALDH1A1NPSR1POLB | |
| SCHEMBL30865420 | 0.70 | HPGD (0.79) | GFERALDH1A1HPGDSMN1; SMN2HTT | |
| SCHEMBL30865488 | 0.70 | HPGD (0.79) | GFERALDH1A1HPGDSMN1; SMN2HTT | |
| SCHEMBL30865440 | 0.70 | HPGD (0.79) | GFERALDH1A1HPGDSMN1; SMN2HTT | |
| SCHEMBL30865472 | 0.70 | HPGD (0.79) | GFERALDH1A1HPGDSMN1; SMN2HTT | |
| SCHEMBL30865492 | 0.70 | HPGD (0.79) | GFERALDH1A1HPGDSMN1; SMN2HTT | |
| Tert-Butyl Formate SCHEMBL27834703 | 0.69 | ALDH1A1 (0.65) | KDM4EGAAALDH1A1NPSR1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318368-A1 | 1-(4-UREIDOBENZOYL)PIPERAZINE DERIVATIVES | N.V. Organon (NL) | 2011-05-11 | — | — | EP | disclosed |
| WO-2010025179-A1 | 1-(4-UREIDOBENZOYL)PIPERAZINE DERIVATIVES | N.V. ORGANON (NL) | 2010-03-04 | — | — | WO | disclosed |