SCHEMBL18274698

SCHEMBL18274698

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nearest known ligand 0.52

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.52
ALDH1A1 P00352 1/20 0.52
CYP1A2 P05177 1/20 0.52
THRB P10828 1/20 0.52
KMT2A Q03164 1/20 0.52
ARG1 P05089 3/20 0.45
ARG2 P78540 3/20 0.45
ODC1 P11926 1/20 0.34
NOS3 P29474 1/20 0.33
NOS1 P29475 1/20 0.33
NOS2 P35228 1/20 0.33
HTR2C P28335 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18274701 0.81 CYP1A2 (0.46) MEN1ALDH1A1CYP1A2THRBKMT2A
SCHEMBL19387343 0.76 HTR2C (0.36) CYP1A2HTR2C
SCHEMBL1434579 0.75 GRM4 (0.35) HTR2C
SCHEMBL5324175 0.74 MEN1 (0.65) MEN1ALDH1A1CYP1A2THRBKMT2A
Hydrochloric Acid SCHEMBL27995083 0.74 NAAA (0.43) MEN1ALDH1A1CYP1A2THRBKMT2A
SCHEMBL16881654 0.72 HTR2C (0.35) HTR2C
SCHEMBL27832570 0.72 MEN1 (0.53) MEN1ALDH1A1CYP1A2THRBKMT2A
SCHEMBL24163861 0.72 MEN1 (0.68) MEN1ALDH1A1CYP1A2THRBKMT2A
SCHEMBL6759254 0.72 MEN1 (0.68) MEN1ALDH1A1CYP1A2THRBKMT2A
SCHEMBL6759253 0.72 MEN1 (0.68) MEN1ALDH1A1CYP1A2THRBKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10919840-B2 Diamine crosslinking agents, crosslinked acidic polysaccharides and medical materials SEIKAGAKU CORPORATION (JP) 2021-02-16 US disclosed
EP-3101064-B1 DIAMINE CROSSLINKING AGENT, ACIDIC POLYSACCHARIDE CROSSLINKED BODY, AND MEDICAL MATERIAL SEIKAGAKU KOGYO CO LTD (JP) 2020-07-15 EP disclosed
US-20190345312-A1 DIAMINE CROSSLINKING AGENTS, CROSSLINKED ACIDIC POLYSACCHARIDES AND MEDICAL MATERIALS SEIKAGAKU CORPORATION (JP) 2019-11-14 US disclosed
US-10294195-B2 Diamine crosslinking agents, crosslinked acidic polysaccharides and medical materials SEIKAGAKU CORPORATION (JP) 2019-05-21 US disclosed
US-20170001948-A1 DIAMINE CROSSLINKING AGENTS, CROSSLINKED ACIDIC POLYSACCHARIDES AND MEDICAL MATERIALS SEIKAGAKU CORPORATION (JP) 2017-01-05 US disclosed
EP-3101064-A1 DIAMINE CROSSLINKING AGENT, ACIDIC POLYSACCHARIDE CROSSLINKED BODY, AND MEDICAL MATERIAL Seikagaku Corporation (JP) 2016-12-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10294195-B2 Diamine crosslinking agents, crosslinked acidic polysaccharides and medical materials SAT1, ACMSD, ADM2 MEN1 2165/4885ALDH1A1 293/4885CYP1A2 3928/4885
US-20170001948-A1 DIAMINE CROSSLINKING AGENTS, CROSSLINKED ACIDIC POLYSACCHARIDES AND MEDICAL MATERIALS SAT1, ACMSD, ADM2 MEN1 2165/4885ALDH1A1 293/4885CYP1A2 3928/4885
US-10919840-B2 Diamine crosslinking agents, crosslinked acidic polysaccharides and medical materials SAT1, ACMSD, ADM2 MEN1 2165/4885ALDH1A1 293/4885CYP1A2 3928/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.