Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 9/20 | 0.57 |
| ▸ | NOS3 | P29474 | 3/20 | 0.57 |
| ▸ | NOS1 | P29475 | 3/20 | 0.57 |
| ▸ | NOS2 | P35228 | 3/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.57 |
| ▸ | ALPI | P09923 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | XIAP | P98170 | 1/20 | 0.57 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16861142 | 1.00 | SLC7A5 (0.57) | SLC7A5NOS3NOS1NOS2PTGS1 | |
| SCHEMBL22444601 | 0.88 | SLC7A5 (0.61) | SLC7A5NOS3NOS1NOS2PTGS1 | |
| SCHEMBL16291101 | 0.88 | SLC7A5 (0.61) | SLC7A5NOS3NOS1NOS2PTGS1 | |
| SCHEMBL6746248 | 0.86 | SLC7A5 (0.59) | SLC7A5NOS3NOS1NOS2PTGS1 | |
| SCHEMBL5566682 | 0.85 | SLC7A5 (0.57) | SLC7A5NOS3NOS1NOS2PTGS1 | |
| SCHEMBL16861128 | 0.84 | SLC7A5 (0.50) | SLC7A5NOS3NOS1NOS2PTGS1 | |
| SCHEMBL18280224 | 0.84 | SLC7A5 (0.50) | SLC7A5NOS3NOS1NOS2PTGS1 | |
| SCHEMBL7258408 | 0.82 | SLC7A5 (0.57) | SLC7A5NOS3NOS1NOS2PTGS1 | |
| SCHEMBL2314258 | 0.82 | SLC7A5 (0.77) | SLC7A5NOS3NOS1NOS2PTGS1 | |
| SCHEMBL16291076 | 0.81 | SLC7A5 (0.66) | SLC7A5NOS3NOS1NOS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12359192-B2 | Methods and compositions for display of macrocyclic peptides | UNIVERSITY OF ROCHESTER (US) | 2025-07-15 | — | — | US | claimed |
| US-20250197448-A1 | CYCLOPEPTIBODIES AND USES THEREOF | UNIVERSITY OF ROCHESTER (US) | 2025-06-19 | — | — | US | claimed |
| EP-3087088-B1 | METHODS AND COMPOSITIONS FOR RIBOSOMAL SYNTHESIS OF MACROCYCLIC PEPTIDES | UNIV ROCHESTER (US) | 2022-05-25 | — | — | EP | claimed |
| US-20200299675-A1 | Methods and Compositions for Display of Macrocyclic Peptides | UNIVERSITY OF ROCHESTER | 2020-09-24 | — | — | US | claimed |
| US-10544191-B2 | Methods and compositions for ribosomal synthesis of macrocyclic peptides | UNIVERSITY OF ROCHESTER (US) | 2020-01-28 | — | — | US | claimed |
| US-20160355552-A1 | METHODS AND COMPOSITIONS FOR RIBOSOMAL SYNTHESIS OF MACROCYCLIC PEPTIDES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-12-08 | — | — | US | claimed |
| US-12359192-B2 | Methods and compositions for display of macrocyclic peptides | UNIVERSITY OF ROCHESTER (US) | 2025-07-15 | — | — | US | disclosed |
| US-20250197448-A1 | CYCLOPEPTIBODIES AND USES THEREOF | UNIVERSITY OF ROCHESTER (US) | 2025-06-19 | — | — | US | disclosed |
| EP-4490202-A1 | CYCLOPEPTIBODIES AND USES THEREOF | University of Rochester (US) | 2025-01-15 | — | — | EP | disclosed |
| WO-2023173084-A9 | CYCLOPEPTIBODIES AND USES THEREOF | UNIVERSITY OF ROCHESTER (US) | 2023-12-14 | — | — | WO | disclosed |
| WO-2023173084-A1 | CYCLOPEPTIBODIES AND USES THEREOF | UNIVERSITY OF ROCHESTER (US) | 2023-09-14 | — | — | WO | disclosed |
| EP-4122945-A1 | METHODS AND COMPOSITIONS FOR RIBOSOMAL SYNTHESIS OF MACROCYCLIC PEPTIDES | University of Rochester (US) | 2023-01-25 | — | — | EP | disclosed |
| EP-3087088-B1 | METHODS AND COMPOSITIONS FOR RIBOSOMAL SYNTHESIS OF MACROCYCLIC PEPTIDES | UNIV ROCHESTER (US) | 2022-05-25 | — | — | EP | disclosed |
| US-20200299675-A1 | Methods and Compositions for Display of Macrocyclic Peptides | UNIVERSITY OF ROCHESTER | 2020-09-24 | — | — | US | disclosed |
| US-10544191-B2 | Methods and compositions for ribosomal synthesis of macrocyclic peptides | UNIVERSITY OF ROCHESTER (US) | 2020-01-28 | — | — | US | disclosed |
| US-20160355552-A1 | METHODS AND COMPOSITIONS FOR RIBOSOMAL SYNTHESIS OF MACROCYCLIC PEPTIDES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12359192-B2 | Methods and compositions for display of macrocyclic peptides | NGLY1, MICA, MRPL21 | SLC7A5 1926/4885NOS3 4493/4885NOS1 4676/4885 |
| US-10544191-B2 | Methods and compositions for ribosomal synthesis of macrocyclic peptides | MRPS27, MRPL21, RPLP2 | SLC7A5 2530/4885NOS3 4125/4885NOS1 4160/4885 |
| US-20250197448-A1 | CYCLOPEPTIBODIES AND USES THEREOF | FCGR3B, FCGRT, FCGR2A | SLC7A5 2011/4885NOS3 2600/4885NOS1 2714/4885 |
| US-20160355552-A1 | METHODS AND COMPOSITIONS FOR RIBOSOMAL SYNTHESIS OF MACROCYCLIC PEPTIDES | MRPS27, MRPL21, RPLP2 | SLC7A5 2530/4885NOS3 4125/4885NOS1 4160/4885 |
| US-20200299675-A1 | Methods and Compositions for Display of Macrocyclic Peptides | SPOUT1, NGLY1, VIP | SLC7A5 1358/4885NOS3 4587/4885NOS1 4588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.