SCHEMBL18280712

SCHEMBL18280712

O=C(O)c1cccnc1-n1c2ccccc2c2ccc(Br)cc21

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MYC P01106 1/20 0.53
ALDH1A1 P00352 2/20 0.47
KMT2A Q03164 4/20 0.43
MEN1 O00255 2/20 0.43
RXFP1 Q9HBX9 1/20 0.43
KDM4E B2RXH2 4/20 0.41
SORT1 Q99523 2/20 0.41
AKR1C3 P42330 1/20 0.39
AKR1C1 Q04828 1/20 0.39
L3MBTL1 Q9Y468 2/20 0.39
KDM6B O15054 1/20 0.39
KDM6A O15550 1/20 0.39
TET3 O43151 1/20 0.39
KDM4A O75164 1/20 0.39
KDM4B O94953 1/20 0.39
KDM5C P41229 1/20 0.39
KDM4D Q6B0I6 1/20 0.39
TET2 Q6N021 1/20 0.39
ALKBH5 Q6P6C2 1/20 0.39
TET1 Q8NFU7 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18280699 0.86 GAA (0.49) MYCALDH1A1RXFP1KDM4ETDP1
SCHEMBL12166117 0.79 GAA (0.49) MYCALDH1A1RXFP1KDM4EL3MBTL1
SCHEMBL18280705 0.77 DDB1 (0.34) ALDH1A1KDM4EMAPTSMN1; SMN2
SCHEMBL25315400 0.76 DDB1 (0.35)
SCHEMBL12077685 0.73 MEN1 (0.43) ALDH1A1KMT2AMEN1KDM4EL3MBTL1
SCHEMBL29668152 0.73 MEN1 (0.43) ALDH1A1KMT2AMEN1KDM4EL3MBTL1
SCHEMBL12166081 0.72 KDM4E (0.52) MYCALDH1A1KMT2AMEN1RXFP1
SCHEMBL18280711 0.71 ALDH1A1 (0.52) ALDH1A1KMT2ARXFP1KDM4ETDP1
SCHEMBL17255936 0.70 FEN1 (0.46) ALDH1A1KDM4EL3MBTL1TSHR
SCHEMBL20699878 0.70 POLB (0.47) ALDH1A1KMT2AMEN1RXFP1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260035398-A1 TETRADENTATE AND OCTAHEDRAL METAL COMPLEXES CONTAINING NAPHTHYRIDINOCARBAZOLE AND ITS ANALOGUES UNIV ARIZONA STATE (US) 2026-02-05 US disclosed
US-12312366-B2 Tetradentate and octahedral metal complexes containing naphthyridinocarbazole and its analogues ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2025-05-27 US disclosed
US-20230115701-A1 TETRADENTATE AND OCTAHEDRAL METAL COMPLEXES CONTAINING NAPHTHYRIDINOCARBAZOLE AND ITS ANALOGUES UNIV ARIZONA STATE (US) 2023-04-13 US disclosed
US-11472827-B2 Tetradentate and octahedral metal complexes containing naphthyridinocarbazole and its analogues ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2022-10-18 US disclosed
US-20210024559-A1 TETRADENTATE AND OCTAHEDRAL METAL COMPLEXES CONTAINING NAPHTHYRIDINOCARBAZOLE AND ITS ANALOGUES UNIV ARIZONA STATE (US) 2021-01-28 US disclosed
US-10836785-B2 Tetradentate and octahedral metal complexes containing naphthyridinocarbazole and its analogues ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2020-11-17 US disclosed
US-20180148464-A1 TETRADENTATE AND OCTAHEDRAL METAL COMPLEXES CONTAINING NAPHTHYRIDINOCARBAZOLE AND ITS ANALOGUES ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY 2018-05-31 US disclosed
US-9879039-B2 Tetradentate and octahedral metal complexes containing naphthyridinocarbazole and its analogues ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2018-01-30 US disclosed
US-9617291-B2 Tetradentate and octahedral metal complexes containing naphthyridinocarbazole and its analogues ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2017-04-11 US disclosed
US-20170066792-A1 TETRADENTATE AND OCTAHEDRAL METAL COMPLEXES CONTAINING NAPHTHYRIDINOCARBAZOLE AND ITS ANALOGUES ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY 2017-03-09 US disclosed
US-20160359125-A1 TETRADENTATE AND OCTAHEDRAL METAL COMPLEXES CONTAINING NAPHTHYRIDINOCARBAZOLE AND ITS ANALOGUES ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY 2016-12-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10836785-B2 Tetradentate and octahedral metal complexes containing naphthyridinocarbazole and its analogues PAICS, DNTT, PNPO MYC 1719/4885ALDH1A1 4508/4885KMT2A 2702/4885
US-20260035398-A1 TETRADENTATE AND OCTAHEDRAL METAL COMPLEXES CONTAINING NAPHTHYRIDINOCARBAZOLE AND ITS ANALOGUES LBR, SCO2, RAD54L MYC 2610/4885ALDH1A1 2242/4885KMT2A 4208/4885
US-20230115701-A1 TETRADENTATE AND OCTAHEDRAL METAL COMPLEXES CONTAINING NAPHTHYRIDINOCARBAZOLE AND ITS ANALOGUES PAICS, DNTT, PNPO MYC 1719/4885ALDH1A1 4508/4885KMT2A 2702/4885
US-12312366-B2 Tetradentate and octahedral metal complexes containing naphthyridinocarbazole and its analogues PAICS, DNTT, PNPO MYC 1719/4885ALDH1A1 4508/4885KMT2A 2702/4885
US-11472827-B2 Tetradentate and octahedral metal complexes containing naphthyridinocarbazole and its analogues PAICS, DNTT, PNPO MYC 1719/4885ALDH1A1 4508/4885KMT2A 2702/4885
US-20170066792-A1 TETRADENTATE AND OCTAHEDRAL METAL COMPLEXES CONTAINING NAPHTHYRIDINOCARBAZOLE AND ITS ANALOGUES PAICS, DNTT, PNPO MYC 1719/4885ALDH1A1 4508/4885KMT2A 2702/4885
US-20180148464-A1 TETRADENTATE AND OCTAHEDRAL METAL COMPLEXES CONTAINING NAPHTHYRIDINOCARBAZOLE AND ITS ANALOGUES PAICS, DNTT, PNPO MYC 1719/4885ALDH1A1 4508/4885KMT2A 2702/4885
US-20160359125-A1 TETRADENTATE AND OCTAHEDRAL METAL COMPLEXES CONTAINING NAPHTHYRIDINOCARBAZOLE AND ITS ANALOGUES PAICS, DNTT, PNPO MYC 1719/4885ALDH1A1 4508/4885KMT2A 2702/4885
US-20210024559-A1 TETRADENTATE AND OCTAHEDRAL METAL COMPLEXES CONTAINING NAPHTHYRIDINOCARBAZOLE AND ITS ANALOGUES PAICS, DNTT, PNPO MYC 1719/4885ALDH1A1 4508/4885KMT2A 2702/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.