⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10840027 | 0.83 | MTNR1A (0.35) | — | |
| SCHEMBL1828739 | 0.80 | KDM4E (0.37) | — | |
| SCHEMBL294912 | 0.79 | — | — | |
| SCHEMBL9759569 | 0.78 | TGFBR1 (0.39) | — | |
| SCHEMBL13411703 | 0.78 | KDM4E (0.43) | — | |
| SCHEMBL1866034 | 0.78 | KDM4E (0.43) | — | |
| SCHEMBL7826230 | 0.78 | — | — | |
| SCHEMBL1866035 | 0.78 | KDM4E (0.43) | — | |
| SCHEMBL10311744 | 0.76 | — | — | |
| SCHEMBL983886 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102766183-A | Anti-HIV-1 fusion activity-modified nucleic acid structure | INST PHARM & TOXICOLOGY AMMS | 2012-11-07 | — | — | CN | claimed |
| CN-102766183-B | There is the nucleic acid structure of the modification of anti-HIV-1 fusion activity | 中国人民解放军军事医学科学院毒物药物研究所 | 2016-09-14 | — | — | CN | disclosed |
| US-8735387-B2 | Oxazolopyrimidines as Edg-1 receptor agonists | SANOFI (FR) | 2014-05-27 | — | — | US | disclosed |
| CN-102159582-B | Oxazolopyrimidines as edg-1 receptor agonists | SANOFI AVENTIS | 2014-05-07 | — | — | CN | disclosed |
| EP-2583720-A1 | Oxazolopyrimidines as Edg-1 receptor agonists | SANOFI (FR) | 2013-04-24 | — | — | EP | disclosed |
| CN-102766183-A | Anti-HIV-1 fusion activity-modified nucleic acid structure | INST PHARM & TOXICOLOGY AMMS | 2012-11-07 | — | — | CN | disclosed |
| CN-102159582-A | Oxazolopyrimidines as edg-1 receptor agonists | SANOFI AVENTIS | 2011-08-17 | — | — | CN | disclosed |
| US-20110190490-A1 | OXAZOLOPYRIMIDINES AS EDG-1 RECEPTOR AGONISTS | SANOFI-AVENTIS (FR) | 2011-08-04 | — | — | US | disclosed |
| EP-2318415-A1 | OXAZOLOPYRIMIDINES AS EDG-1 RECEPTOR AGONISTS | Sanofi-Aventis (FR) | 2011-05-11 | — | — | EP | disclosed |
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |
| WO-2010006704-A1 | OXAZOLOPYRIMIDINES AS EDG-1 RECEPTOR AGONISTS | SANOFI-AVENTIS (FR) | 2010-01-21 | — | — | WO | disclosed |