Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8068207 | 0.85 | ALDH1A1 (0.36) | ALDH1A1TSHR | |
| SCHEMBL8057836 | 0.85 | ALDH1A1 (0.36) | ALDH1A1TSHR | |
| SCHEMBL8068986 | 0.77 | MEN1 (0.30) | — | |
| SCHEMBL20658227 | 0.77 | ALDH1A1 (0.33) | ALDH1A1TSHR | |
| SCHEMBL8069328 | 0.77 | MEN1 (0.39) | TSHR | |
| SCHEMBL8057662 | 0.77 | MEN1 (0.39) | TSHR | |
| SCHEMBL8066787 | 0.77 | MEN1 (0.30) | — | |
| SCHEMBL5561419 | 0.74 | — | — | |
| SCHEMBL4845914 | 0.74 | — | — | |
| SCHEMBL242589 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9012435-B2 | Glucocorticoids attached to nitrate esters via an aromatic linker in position 21 and their use in ophthalmology | NICOX S.A. (FR) | 2015-04-21 | — | — | US | disclosed |
| US-20130303499-A1 | GLUCOCORTICOIDS ATTACHED TO NITRATE ESTERS VIA AN AROMATIC LINKER IN POSITION 21 AND THEIR USE IN OPHTHALMOLOGY | NICOX S.A. (FR) | 2013-11-14 | — | — | US | disclosed |
| EP-2318427-B1 | GLUCOCORTICOIDS ATTACHED TO NITRATE ESTERS VIA AN AROMATIC LINKER IN POSITION 21 AND THEIR USE IN OPHTHALMOLOGY | NICOX SA (FR) | 2013-10-23 | — | — | EP | disclosed |
| US-8518920-B2 | Glucocorticoids attached to nitrate esters via an aromatic linker in position 21 and their use in ophthalmology | NICOX S.A. (FR) | 2013-08-27 | — | — | US | disclosed |
| US-20110144073-A1 | GLUCOCORTICOIDS ATTACHED TO NITRATE ESTERS VIA AN AROMATIC LINKER IN POSITION 21 AND THEIR USE IN OPHTHALMOLOGY | NICOX S.A. | 2011-06-16 | — | — | US | disclosed |
| EP-2318427-A1 | GLUCOCORTICOIDS ATTACHED TO NITRATE ESTERS VIA AN AROMATIC LINKER IN POSITION 21 AND THEIR USE IN OPHTHALMOLOGY | Nicox S.A. (FR) | 2011-05-11 | — | — | EP | disclosed |
| WO-2010012567-A1 | GLUCOCORTICOIDS ATTACHED TO NITRATE ESTERS VIA AN AROMATIC LINKER IN POSITION 21 AND THEIR USE IN OPHTHALMOLOGY | NICOX S.A. (FR) | 2010-02-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144073-A1 | GLUCOCORTICOIDS ATTACHED TO NITRATE ESTERS VIA AN AROMATIC LINKER IN POSITION 21 AND THEIR USE IN OPHTHALMOLOGY | NR3C1, NR3C2, CYP11B1 | ALDH1A1 3559/4885TSHR 1435/4885 |
| US-20130303499-A1 | GLUCOCORTICOIDS ATTACHED TO NITRATE ESTERS VIA AN AROMATIC LINKER IN POSITION 21 AND THEIR USE IN OPHTHALMOLOGY | NR3C1, NR3C2, CYP11B1 | ALDH1A1 3559/4885TSHR 1435/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.