Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23663105 | 0.65 | ALDH1A1 (0.45) | MAPT | |
| SCHEMBL17272789 | 0.62 | MAPT (0.61) | MAPT | |
| SCHEMBL18282729 | 0.61 | DYRK1A (0.41) | — | |
| SCHEMBL30581101 | 0.58 | HCAR2 (0.38) | — | |
| Uric Acid SCHEMBL2786719 | 0.58 | MAPT (0.53) | MAPT | |
| SCHEMBL9525206 | 0.57 | — | — | |
| SCHEMBL23909022 | 0.56 | PARP1 (0.57) | — | |
| SCHEMBL18283136 | 0.55 | TYMS (0.41) | — | |
| SCHEMBL24284153 | 0.55 | — | — | |
| SCHEMBL4817305 | 0.55 | PRMT5 (0.68) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016192083-A1 | DIHYDROPYRAZOLOPYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-12-08 | — | — | WO | disclosed |