⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3302769 | 0.69 | — | — | |
| SCHEMBL23663105 | 0.62 | ALDH1A1 (0.45) | — | |
| SCHEMBL30581101 | 0.60 | HCAR2 (0.38) | — | |
| SCHEMBL1628568 | 0.59 | — | — | |
| SCHEMBL18107147 | 0.58 | HCAR2 (0.50) | — | |
| SCHEMBL23909022 | 0.57 | PARP1 (0.57) | — | |
| SCHEMBL11528858 | 0.57 | CYP1A2 (0.41) | — | |
| SCHEMBL23147179 | 0.57 | HCAR2 (0.42) | — | |
| SCHEMBL11603299 | 0.57 | — | — | |
| SCHEMBL18284394 | 0.57 | MAPT (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276805-B1 | Substituted 3-phenyl-7H-thiazolo[3,2-b][1,2,4]triazin-7-ones, processes for their preparation, medicaments containing them and their use as well as some of the intermediates obtained during the preparation of said compounds | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-03-17 | — | — | EP | disclosed |
| US-4908364-A | Pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-03-13 | — | — | US | disclosed |
| EP-0276805-A2 | Substituted 3-phenyl-7H-thiazolo[3,2-b][1,2,4]triazin-7-ones, processes for their preparation, medicaments containing them and their use as well as some of the intermediates obtained during the preparation of said compounds | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-08-03 | — | — | EP | disclosed |