Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 5/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.37 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 2/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29727621 | 0.88 | TYRO3 (0.39) | TYRO3CNR1HDAC2HDAC1SCN10A | |
| SCHEMBL18285278 | 0.88 | TYRO3 (0.39) | TYRO3CNR1HDAC2HDAC1SCN10A | |
| SCHEMBL18512789 | 0.86 | SCN10A (0.42) | TYRO3CNR1CNR2HDAC2HDAC3 | |
| SCHEMBL18285284 | 0.85 | CNR1 (0.37) | TYRO3CNR1CNR2HDAC2SCN10A | |
| SCHEMBL29727626 | 0.84 | JAK2 (0.45) | HDAC2SCN10AIKBKBPTPN1 | |
| SCHEMBL18285282 | 0.84 | JAK2 (0.45) | HDAC2SCN10AIKBKBPTPN1 | |
| SCHEMBL18285338 | 0.81 | HTT (0.40) | — | |
| SCHEMBL18706012 | 0.80 | WDR5 (0.37) | TYRO3CNR1CNR2SCN10AIKBKB | |
| SCHEMBL18172352 | 0.77 | P2RY14 (0.41) | HPGDS | |
| SCHEMBL18496598 | 0.77 | ABL1 (0.40) | SCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107531642-B | Imidazole derivatives | 豪夫迈·罗氏有限公司 | 2021-06-22 | — | — | CN | disclosed |
| CN-107922391-B | Pyridine and pyrimidine derivatives | 豪夫迈·罗氏有限公司 | 2020-09-25 | — | — | CN | disclosed |
| EP-3334727-B1 | PYRIDINE AND PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2019-05-15 | — | — | EP | disclosed |
| EP-3303299-B1 | IMIDAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2019-04-24 | — | — | EP | disclosed |
| US-10029989-B2 | Imidazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2018-07-24 | — | — | US | disclosed |
| US-10005736-B1 | Pyridine and pyrimidine derivatives | HOFFMAN-LA ROCHE INC. (US) | 2018-06-26 | — | — | US | disclosed |
| EP-3334727-A1 | PYRIDINE AND PYRIMIDINE DERIVATIVES | H. Hoffnabb-La Roche Ag (CH) | 2018-06-20 | — | — | EP | disclosed |
| US-20180162824-A1 | PYRIDINE AND PYRIMIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2018-06-14 | — | — | US | disclosed |
| US-20180118692-A1 | IMIDAZOLE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2018-05-03 | — | — | US | disclosed |
| EP-3303299-A1 | IMIDAZOLE DERIVATIVES | H. Hoffnabb-La Roche Ag (CH) | 2018-04-11 | — | — | EP | disclosed |
| WO-2017025523-A1 | PYRIDINE AND PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2017-02-16 | — | — | WO | disclosed |
| WO-2016193235-A1 | IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2016-12-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180162824-A1 | PYRIDINE AND PYRIMIDINE DERIVATIVES | MC3R, MC2R, NPY1R | TYRO3 930/4885CNR1 14/4885CNR2 157/4885 |
| US-20180118692-A1 | IMIDAZOLE DERIVATIVES | DRD3, GABRR3, DRD4 | TYRO3 816/4885CNR1 214/4885CNR2 590/4885 |
| US-10029989-B2 | Imidazole derivatives | DRD3, GABRR3, DRD4 | TYRO3 816/4885CNR1 214/4885CNR2 590/4885 |
| US-10005736-B1 | Pyridine and pyrimidine derivatives | MC3R, MC2R, NPY1R | TYRO3 930/4885CNR1 14/4885CNR2 157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.