SCHEMBL18285465

SCHEMBL18285465

Nc1ncnc2nc(-c3ccc(N4CCC(O)(C5COC(=O)C5)CC4)nn3)cc(-c3cccc(Br)c3)c12

nearest known ligand 0.61

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ ADK P55263 19/20 0.61
▸ KDM4E B2RXH2 1/20 0.52
▸ MEN1 O00255 1/20 0.52
▸ ALDH1A1 P00352 1/20 0.52
▸ MAPT P10636 1/20 0.52
▸ HPGD P15428 1/20 0.52
▸ ALOX15 P16050 1/20 0.52
▸ TSHR P16473 1/20 0.52
▸ CASP1 P29466 1/20 0.52
▸ BLM P54132 1/20 0.52
▸ CASP7 P55210 1/20 0.52
▸ KMT2A Q03164 1/20 0.52
▸ SMN1; SMN2 Q16637 1/20 0.52
▸ HSD17B10 Q99714 1/20 0.52
▸ TDP1 Q9NUW8 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8194050 0.81 ADK (0.79) ADKKDM4EMEN1ALDH1A1MAPT
SCHEMBL20187278 0.80 ADK (0.66) ADKKDM4EMEN1ALDH1A1MAPT
SCHEMBL8214430 0.80 ADK (0.67) ADKKDM4EMEN1ALDH1A1MAPT
SCHEMBL2038363 0.80 ADK (0.75) ADKKDM4EMEN1ALDH1A1MAPT
SCHEMBL18285643 0.79 ADK (0.77) ADKKDM4EMEN1ALDH1A1MAPT
SCHEMBL8392353 0.79 ADK (0.73) ADKKDM4EMEN1ALDH1A1MAPT
SCHEMBL2038690 0.79 ADK (0.74) ADKKDM4EMEN1ALDH1A1MAPT
SCHEMBL8219181 0.79 ADK (0.72) ADKKDM4EMEN1ALDH1A1MAPT
SCHEMBL8251742 0.79 ADK (0.67) ADKKDM4EMEN1ALDH1A1MAPT
SCHEMBL8197173 0.79 ADK (0.61) ADKKDM4EMEN1ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180148428-A1 ORGANIC LIGHT EMITTING DEVICE WITH THERMALLY ACTIVATED DELAYED FLUORESCENT LIGHT EMITTING MATERIAL COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2018-05-31 — — US disclosed
WO-2016191803-A1 ORGANIC LIGHT EMITTING DEVICE WITH THERMALLY ACTIVATED DELAYED FLUORESCENT LIGHT EMITTING MATERIAL COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2016-12-08 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180148428-A1 ORGANIC LIGHT EMITTING DEVICE WITH THERMALLY ACTIVATED DELAYED FLUORESCENT LIGHT EMITTING MATERIAL OCIAD1, OCIAD2, TRPA1 ADK 2764/4885KDM4E 4198/4885MEN1 4579/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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