Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL610480 | 0.90 | TP53 (0.69) | TP53TSHRKEAP1MAPK1ALDH1A1 | |
| SCHEMBL29822323 | 0.90 | TP53 (0.69) | TP53TSHRKEAP1MAPK1ALDH1A1 | |
| SCHEMBL1827691 | 0.82 | TP53 (0.60) | TP53TSHRKEAP1MAPK1ALDH1A1 | |
| SCHEMBL143826 | 0.81 | TP53 (0.65) | TP53TSHRKEAP1MAPK1ALDH1A1 | |
| SCHEMBL2161705 | 0.81 | TP53 (0.58) | TP53TSHRKEAP1MAPK1ALDH1A1 | |
| SCHEMBL609145 | 0.79 | TP53 (0.56) | TP53TSHRKEAP1MAPK1ALDH1A1 | |
| SCHEMBL150008 | 0.78 | TSHR (0.75) | TP53TSHRKEAP1MAPK1ALDH1A1 | |
| SCHEMBL29381824 | 0.78 | TSHR (0.75) | TP53TSHRKEAP1MAPK1ALDH1A1 | |
| SCHEMBL6647138 | 0.78 | TP53 (0.55) | TP53TSHRKEAP1MAPK1ALDH1A1 | |
| SCHEMBL29478348 | 0.78 | TSHR (0.62) | TP53TSHRKEAP1MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318374-A2 | INSECTICIDAL BENZENEDICARBOXAMIDE DERIVATIVE | Bayer CropScience AG (DE) | 2011-05-11 | — | — | EP | disclosed |
| WO-2010012442-A2 | INSECTICIDAL BENZENEDICARBOXAMIDE DERIVATIVE | BAYER CROPSCIENCE AG (DE) | 2010-02-04 | — | — | WO | disclosed |