Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.62 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.56 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | CA6 | P23280 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL288796 | 1.00 | TSHR (0.62) | TSHRHSP90AA1HSP90AB1TP53KEAP1 | |
| Alcohol SCHEMBL28109153 | 0.96 | TSHR (0.59) | TSHRHSP90AA1HSP90AB1TP53KEAP1 | |
| SCHEMBL266244 | 0.88 | TSHR (0.58) | TSHRHSP90AA1HSP90AB1TP53KEAP1 | |
| SCHEMBL29822323 | 0.87 | TP53 (0.69) | TSHRHSP90AA1HSP90AB1TP53KEAP1 | |
| SCHEMBL610480 | 0.87 | TP53 (0.69) | TSHRHSP90AA1HSP90AB1TP53KEAP1 | |
| SCHEMBL10146384 | 0.86 | TSHR (0.53) | TSHRHSP90AA1HSP90AB1TP53KEAP1 | |
| SCHEMBL6371982 | 0.82 | KDM4E (0.64) | TSHRTP53KEAP1MAPK1ALDH1A1 | |
| SCHEMBL30337088 | 0.82 | TP53 (0.62) | TSHRTP53TDP1ALDH1A1HPGD | |
| SCHEMBL28972723 | 0.82 | TP53 (0.62) | TSHRTP53TDP1ALDH1A1HPGD | |
| SCHEMBL150008 | 0.80 | TSHR (0.75) | TSHRTP53KEAP1TDP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4731209-A1 | PROCESSES FOR PREPARING SOLUBLE GUANYLATE CYCLASE STIMULATORS | Merck Sharp & Dohme LLC (US) | 2026-04-29 | — | — | EP | claimed |
| WO-2025006295-A1 | PROCESSES FOR PREPARING SOLUBLE GUANYLATE CYCLASE STIMULATORS | MERCK SHARP & DOHME LLC (US) | 2025-01-02 | — | — | WO | claimed |
| US-12358916-B2 | Substituted heterocycle fused gamma-carbolines synthesis | INTRA-CELLULAR THERAPIES, INC. (US) | 2025-07-15 | — | — | US | disclosed |
| US-12297200-B2 | Substituted heterocycle fused gamma-carbolines synthesis | INTRA-CELLULAR THERAPIES, INC. (US) | 2025-05-13 | — | — | US | disclosed |
| WO-2025026436-A1 | NITROGEN-CONTAINING FUSED RING COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 韦恩生物科技有限公司 | 2025-02-06 | — | — | WO | disclosed |
| CN-114539167-B | Process for producing alkynyl ketone derivative | 盐野义制药株式会社 | 2024-12-17 | — | — | CN | disclosed |
| CN-109415352-B | 3-amino-1, 2, 4-triazine derivatives and their use for controlling unwanted plant growth | 拜耳作物科学股份公司 | 2022-04-26 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12358916-B2 | Substituted heterocycle fused gamma-carbolines synthesis | HCCS, CYCS, CBR3 | TSHR 3270/4885HSP90AA1 3102/4885HSP90AB1 3206/4885 |
| US-12297200-B2 | Substituted heterocycle fused gamma-carbolines synthesis | HCCS, CYCS, CBR3 | TSHR 3270/4885HSP90AA1 3102/4885HSP90AB1 3206/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.