Sugi Predict

Sugi Predict / Compounds / SCHEMBL610480

SCHEMBL610480

SCHEMBL610480

CCN(CC)C(=O)c1ccccc1C(=O)N(CC)CC

nearest known ligand 0.69

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ TP53 P04637 1/20 0.69
▸ TSHR P16473 2/20 0.62
▸ KEAP1 Q14145 1/20 0.61
▸ MAPK1 P28482 1/20 0.58
▸ HPGD P15428 4/20 0.57
▸ ALDH1A1 P00352 3/20 0.57
▸ MAPT P10636 3/20 0.57
▸ LMNA P02545 3/20 0.50
▸ L3MBTL1 Q9Y468 1/20 0.50
▸ TDP1 Q9NUW8 1/20 0.50
▸ HSP90AA1 P07900 2/20 0.49
▸ HSP90AB1 P08238 2/20 0.49
▸ ADRA1D P25100 1/20 0.48
▸ ADRA1A P35348 1/20 0.48
▸ ADRA1B P35368 1/20 0.48
▸ TRPA1 O75762 1/20 0.48
▸ ABCC1 P33527 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29822323 1.00 TP53 (0.69) TP53TSHRKEAP1MAPK1HPGD
SCHEMBL1827691 0.92 TP53 (0.60) TP53TSHRKEAP1MAPK1HPGD
SCHEMBL1828569 0.90 TP53 (0.58) TP53TSHRKEAP1MAPK1HPGD
SCHEMBL2161705 0.90 TP53 (0.58) TP53TSHRKEAP1MAPK1HPGD
SCHEMBL609145 0.88 TP53 (0.56) TP53TSHRKEAP1MAPK1HPGD
SCHEMBL150008 0.87 TSHR (0.75) TP53TSHRKEAP1MAPK1HPGD
SCHEMBL29381824 0.87 TSHR (0.75) TP53TSHRKEAP1MAPK1HPGD
SCHEMBL6647138 0.87 TP53 (0.55) TP53TSHRKEAP1MAPK1HPGD
SCHEMBL29478348 0.87 TSHR (0.62) TP53TSHRKEAP1MAPK1HPGD
SCHEMBL288796 0.87 TSHR (0.62) TP53TSHRKEAP1MAPK1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 102 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240074995-A1 METHODS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH AN ABNORMAL INFLAMMATORY RESPONSES FIRST WAVE BIO, INC. 2024-03-07 — — US disclosed
US-11793777-B2 Methods and compositions for treating conditions associated with an abnormal inflammatory response FIRST WAVE BIO, INC. (US) 2023-10-24 — — US disclosed
US-11744812-B2 Methods of treatment FIRST WAVE BIO, INC. (US) 2023-09-05 — — US disclosed
WO-2023118074-A1 COMPRESSIBLE AND FREE FLOWING CO-PROCESSED MESOPOROUS SILICA UNIVERZA V LJUBLJANI (SI) 2023-06-29 — — WO disclosed
US-20230201143-A1 METHODS OF TREATMENT FIRST WAVE BIO, INC. 2023-06-29 — — US disclosed
US-20230190684-A1 METHODS OF TREATING COVID-19 WITH A NICLOSAMIDE COMPOUND FIRST WAVE BIO, INC. 2023-06-22 — — US disclosed
US-20230102999-A1 DEUTERATED NICLOSAMIDE FIRST WAVE BIO, INC. 2023-03-30 — — US disclosed
US-11564896-B2 Methods of treatment FIRST WAVE BIO, INC. (US) 2023-01-31 — — US disclosed
EP-4045480-A1 PHARMACEUTICAL FORMULATIONS First Wave Bio, Inc. (US) 2022-08-24 — — EP disclosed
US-20220105057-A1 METHODS OF TREATMENT FIRST WAVE BIO, INC. 2022-04-07 — — US disclosed
EP-0573938-A2 In-line solvent incorporation for amorphous particle dispersions EASTMAN KODAK COMPANY (US) 1993-12-15 — — EP disclosed
EP-0523470-A2 Complexed hydroquinones POLAROID CORPORATION (US) 1993-01-20 — — EP disclosed
US-5177262-A Hydrogen-Bonded Complex with N,N,N',N'-Tetrasubstituted P-Aromatic Dicarboxamides POLAROID CORPORATION (US) 1993-01-05 — — US disclosed
US-5158979-A Administering iron chelator NEW YORK UNIVERSITY (US) 1992-10-27 — — US disclosed
US-4665410-A THERMOGRAPHY RICOH COMPANY, LTD. (JP) 1987-05-12 — — US disclosed
US-4663641-A LEUCO DYES; DECOLORIZING AGENTS, PIPERAZINE COMPOUND; AMIDES AND TERTIARY AMINES RICOH COMPANY, LTD. (JP) 1987-05-05 — — US disclosed
US-4613878-A DECOLORIZING AGENT COMPRISING AROMATIC DIAMIDE OR PIPERAZINE DERIVATIVE, HAVING TWO ACYLAMINO GROUPS RICOH COMPANY, LTD. (JP) 1986-09-23 — — US disclosed
EP-0002349-B1 PLASTICIZATION OF NEUTRALIZED SULFONATED ELASTOMERIC POLYMER EXXON RESEARCH AND ENGINEERING COMPANY (US) 1982-09-29 — — EP disclosed
EP-0002349-A1 Plasticization of neutralized sulfonated elastomeric polymer EXXON RESEARCH AND ENGINEERING COMPANY (US) 1979-06-13 — — EP disclosed
US-4118362-A ORGANIC AMIDE EXXON RESEARCH & ENGINEERING CO. (US) 1978-10-03 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240074995-A1 METHODS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH AN ABNORMAL INFLAMMATORY RESPONSES FH, CS, ECHS1 TP53 2529/4885TSHR 4852/4885KEAP1 1576/4885
US-20230190684-A1 METHODS OF TREATING COVID-19 WITH A NICLOSAMIDE COMPOUND ACE2, ACE, MME TP53 1779/4885TSHR 4004/4885KEAP1 4330/4885
US-11744812-B2 Methods of treatment ACE2, ACE, SI TP53 1902/4885TSHR 3982/4885KEAP1 4464/4885
US-20230201143-A1 METHODS OF TREATMENT ACE2, ACE, SI TP53 1573/4885TSHR 4477/4885KEAP1 4207/4885
US-11564896-B2 Methods of treatment ACE2, ACE, SI TP53 1573/4885TSHR 4477/4885KEAP1 4207/4885
US-20220105057-A1 METHODS OF TREATMENT ACE2, ACE, SI TP53 1573/4885TSHR 4477/4885KEAP1 4207/4885
US-20230102999-A1 DEUTERATED NICLOSAMIDE FH, IDH2, ECHS1 TP53 3431/4885TSHR 4789/4885KEAP1 2740/4885
US-11793777-B2 Methods and compositions for treating conditions associated with an abnormal inflammatory response FH, CS, ECHS1 TP53 2568/4885TSHR 4850/4885KEAP1 1536/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.