Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NAAA | Q02083 | 5/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3436851 | 0.75 | RAB9A (0.43) | KDM4EALDH1A1LMNASMN1; SMN2HPGD | |
| SCHEMBL163520 | 0.71 | HTT (0.46) | KDM4EALDH1A1LMNASMN1; SMN2NAAA | |
| SCHEMBL12440555 | 0.70 | NPC1 (0.48) | ALDH1A1LMNASMN1; SMN2HPGDTBXA2R | |
| SCHEMBL30545065 | 0.68 | HPGD (0.64) | KDM4ELMNASMN1; SMN2NAAAL3MBTL1 | |
| SCHEMBL10427993 | 0.67 | DPP7 (0.59) | NAAA | |
| SCHEMBL15662158 | 0.67 | DPP7 (0.59) | NAAA | |
| SCHEMBL16414566 | 0.67 | DPP7 (0.59) | NAAA | |
| SCHEMBL15660830 | 0.67 | DPP7 (0.59) | NAAA | |
| SCHEMBL15658610 | 0.67 | DPP7 (0.59) | NAAA | |
| SCHEMBL15660958 | 0.67 | DPP7 (0.59) | NAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10858358-B2 | S1PR2 antagonists and uses therefor | DALHOUSIE UNIVERSITY (CA) | 2020-12-08 | — | — | US | disclosed |
| US-20200347058-A1 | S1PR2 ANTAGONISTS AND USES THEREFOR | DALHOUSIE UNIVERSITY (CA) | 2020-11-05 | — | — | US | disclosed |
| US-10487082-B2 | S1PR2 antagonists and uses therefor | DALHOUSIE UNIVERSITY (CA) | 2019-11-26 | — | — | US | disclosed |
| US-20190169187-A1 | S1PR2 ANTAGONISTS AND USES THEREFOR | DALHOUSIE UNIVERSITY (CA) | 2019-06-06 | — | — | US | disclosed |
| US-20190127372-A1 | S1PR2 ANTAGONISTS AND USES THEREFOR | DALHOUSIE UNIVERSITY (CA) | 2019-05-02 | — | — | US | disclosed |
| US-20180141942-A1 | S1PR2 ANTAGONISTS AND USES THEREFOR | DALHOUSIE UNIVERSITY (CA) | 2018-05-24 | — | — | US | disclosed |
| EP-3298014-A1 | S1PR2 ANTAGONISTS AND USES THEREFOR | Dalhousie University (CA) | 2018-03-28 | — | — | EP | disclosed |
| CN-107849038-A | S1PR2 antagonists and application thereof | 达尔豪西大学 | 2018-03-27 | — | — | CN | disclosed |
| WO-2016191872-A1 | S1PR2 ANTAGONISTS AND USES THEREFOR | DALHOUSIE UNIVERSITY (CA) | 2016-12-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10858358-B2 | S1PR2 antagonists and uses therefor | S1PR2, S1PR4, S1PR1 | KDM4E 1437/4885ALDH1A1 3161/4885LMNA 2734/4885 |
| US-20190127372-A1 | S1PR2 ANTAGONISTS AND USES THEREFOR | S1PR2, S1PR4, S1PR1 | KDM4E 1060/4885ALDH1A1 3173/4885LMNA 3512/4885 |
| US-20190169187-A1 | S1PR2 ANTAGONISTS AND USES THEREFOR | S1PR2, S1PR4, S1PR3 | KDM4E 2726/4885ALDH1A1 2267/4885LMNA 3003/4885 |
| US-20200347058-A1 | S1PR2 ANTAGONISTS AND USES THEREFOR | S1PR2, S1PR4, S1PR1 | KDM4E 1060/4885ALDH1A1 3173/4885LMNA 3512/4885 |
| US-20180141942-A1 | S1PR2 ANTAGONISTS AND USES THEREFOR | S1PR2, S1PR4, S1PR1 | KDM4E 1060/4885ALDH1A1 3173/4885LMNA 3512/4885 |
| US-10487082-B2 | S1PR2 antagonists and uses therefor | S1PR2, S1PR4, S1PR3 | KDM4E 2726/4885ALDH1A1 2267/4885LMNA 3003/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.