Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11834166 | 0.86 | GAA (0.51) | GAAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL1186288 | 0.82 | POLB (0.55) | GAAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL1995869 | 0.82 | EPHX1 (0.59) | GAAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL10516773 | 0.82 | MAPT (0.71) | GAAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL3183964 | 0.81 | ALDH1A1 (0.63) | GAAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL68180 | 0.81 | MAPT (0.70) | GAAMAPTALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11879263 | 0.81 | EPHX1 (0.57) | GAAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL10310173 | 0.79 | ALDH1A1 (0.51) | GAAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL61965 | 0.79 | SMN1; SMN2 (0.54) | GAAMAPTALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11511126 | 0.78 | ALDH1A1 (0.45) | GAAMAPTALDH1A1CA2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2605804-B1 | COMPOUNDS AND COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO | UNIV EMORY (US) | 2017-03-15 | — | — | EP | disclosed |
| US-9511071-B2 | Compounds and compositions for ossification and methods related thereto | EMORY UNIVERSITY (US) | 2016-12-06 | — | — | US | disclosed |