SCHEMBL1828858

SCHEMBL1828858

CCCCn1ccnc1OC(=O)C(C)C

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.47
POLB P06746 1/20 0.47
KMT2A Q03164 1/20 0.47
TLR8 Q9NR97 2/20 0.42
SMN1; SMN2 Q16637 2/20 0.38
CYP1A2 P05177 1/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2C9 P11712 1/20 0.37
PKM P14618 1/20 0.37
CYP2C19 P33261 1/20 0.37
ARG1 P05089 1/20 0.36
AGTR1 P30556 1/20 0.35
AGTR2 P50052 1/20 0.35
LMNA P02545 3/20 0.35
NPSR1 Q6W5P4 1/20 0.35
TSHR P16473 1/20 0.34
HTT P42858 1/20 0.34
CNR1 P21554 2/20 0.34
CNR2 P34972 2/20 0.34
NR3C1 P04150 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1829325 0.85 ALDH1A1 (0.53) ALDH1A1POLBKMT2ATLR8SMN1; SMN2
SCHEMBL1829860 0.80 ALDH1A1 (0.47) ALDH1A1POLBKMT2ATLR8SMN1; SMN2
SCHEMBL893369 0.75 ALDH1A1 (0.59) ALDH1A1POLBKMT2ATLR8SMN1; SMN2
SCHEMBL2960713 0.73 ALDH1A1 (0.53) ALDH1A1POLBKMT2ATLR8SMN1; SMN2
SCHEMBL3171422 0.72 ALDH1A1 (0.51) ALDH1A1POLBKMT2ATLR8SMN1; SMN2
SCHEMBL10352847 0.72 TLR8 (0.61) ALDH1A1POLBKMT2ATLR8SMN1; SMN2
SCHEMBL11151350 0.71 POLB (0.36) ALDH1A1POLBKMT2ATLR8SMN1; SMN2
SCHEMBL2488201 0.71 ALDH1A1 (0.39) ALDH1A1POLBKMT2ATLR8SMN1; SMN2
SCHEMBL27486503 0.71 ALDH1A1 (0.54) ALDH1A1POLBKMT2ATLR8SMN1; SMN2
SCHEMBL11050657 0.70 ALDH1A1 (0.57) ALDH1A1POLBKMT2ATLR8SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1861364-B1 PREPARATION OF AN ATORVASTATIN INTERMEDIATE USING A PAAL-KNORR CONDENSATION C P PHARMACEUTICALS INTERNAT C V (US) 2011-05-11 EP claimed
JP-2008533128-A 2008-08-21 JP claimed
EP-1861364-A1 PREPARATION OF AN ATORVASTATIN INTERMEDIATE USING A PAAL-KNORR CONDENSATION Pfizer Science and Technology Ireland Limited (IE) 2007-12-05 EP claimed
WO-2006097909-A1 PREPARATION OF AN ATORVASTATIN INTERMEDIATE USING A PAAL-KNORR CONDENSATION PFIZER SCIENCE AND TECHNOLOGY IRELAND LIMITED (IE) 2006-09-21 WO claimed
EP-1861364-B1 PREPARATION OF AN ATORVASTATIN INTERMEDIATE USING A PAAL-KNORR CONDENSATION C P PHARMACEUTICALS INTERNAT C V (US) 2011-05-11 EP disclosed
EP-1861364-A1 PREPARATION OF AN ATORVASTATIN INTERMEDIATE USING A PAAL-KNORR CONDENSATION Pfizer Science and Technology Ireland Limited (IE) 2007-12-05 EP disclosed
WO-2006097909-A1 PREPARATION OF AN ATORVASTATIN INTERMEDIATE USING A PAAL-KNORR CONDENSATION PFIZER SCIENCE AND TECHNOLOGY IRELAND LIMITED (IE) 2006-09-21 WO disclosed