SCHEMBL1828872

SCHEMBL1828872

O=C(Cc1ccccc1)N1CCC(O)C1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.68
TACR3 P29371 1/20 0.68
POLB P06746 1/20 0.68
L3MBTL1 Q9Y468 1/20 0.65
KDM4E B2RXH2 2/20 0.56
OPRK1 P41145 2/20 0.54
LMNA P02545 1/20 0.53
RAB9A P51151 1/20 0.53
HSD11B1 P28845 1/20 0.53
HDAC3 O15379 1/20 0.51
HDAC4 P56524 1/20 0.51
HDAC1 Q13547 1/20 0.51
HDAC7 Q8WUI4 1/20 0.51
HDAC2 Q92769 1/20 0.51
HDAC10 Q969S8 1/20 0.51
HDAC11 Q96DB2 1/20 0.51
HDAC8 Q9BY41 1/20 0.51
HDAC6 Q9UBN7 1/20 0.51
HDAC9 Q9UKV0 1/20 0.51
HDAC5 Q9UQL6 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12489580 1.00 ALDH1A1 (0.68) ALDH1A1TACR3POLBL3MBTL1KDM4E
SCHEMBL16973965 1.00 ALDH1A1 (0.68) ALDH1A1TACR3POLBL3MBTL1KDM4E
SCHEMBL12945058 0.84 POLB (0.67) ALDH1A1TACR3POLBL3MBTL1TSHR
SCHEMBL12208343 0.84 ALDH1A1 (0.68) ALDH1A1TACR3POLBL3MBTL1KDM4E
SCHEMBL12385822 0.83 ALDH1A1 (0.67) ALDH1A1TACR3POLBL3MBTL1KDM4E
SCHEMBL14197774 0.83 ALDH1A1 (0.67) ALDH1A1TACR3POLBL3MBTL1KDM4E
SCHEMBL27713178 0.83 ALDH1A1 (0.67) ALDH1A1TACR3POLBL3MBTL1KDM4E
SCHEMBL24533902 0.82 POLB (0.56) POLBKDM4EOPRK1RAB9AOPRD1
SCHEMBL2134171 0.81 ALDH1A1 (1.00) ALDH1A1TACR3POLBL3MBTL1KDM4E
SCHEMBL5724695 0.81 GRM5 (0.59) ALDH1A1TACR3POLBRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102177141-B bis-1H-benzimidazoles as hepatitis C virus inhibitors BRISTOL MYERS SQUIBB CO 2014-07-23 CN claimed
CN-102177141-A bis-1H-benzimidazoles as hepatitis C virus inhibitors BRISTOL MYERS SQUIBB CO 2011-09-07 CN claimed
CN-104072486-B As the connection-1H-benzoglyoxaline of hepatitis C virus inhibitors SQUIBB BRISTOL MYERS CO. (US) 2016-04-06 CN disclosed
CN-104072486-A BI-1H-BENZIMIDAZOLES AS HEPATITIS C VIRUS INHIBITORS BRISTOL MYERS SQUIBB CO 2014-10-01 CN disclosed
CN-102177141-B bis-1H-benzimidazoles as hepatitis C virus inhibitors BRISTOL MYERS SQUIBB CO 2014-07-23 CN disclosed
CN-102177141-A bis-1H-benzimidazoles as hepatitis C virus inhibitors BRISTOL MYERS SQUIBB CO 2011-09-07 CN disclosed
EP-2318376-A1 BI-1H-BENZIMIDAZOLES AS HEPATITIS C VIRUS INHIBITORS Bristol-Myers Squibb Company (US) 2011-05-11 EP disclosed
WO-2010017401-A1 BI-1H-BENZIMIDAZOLES AS HEPATITIS C VIRUS INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2010-02-11 WO disclosed