Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | AR | P10275 | 1/20 | 0.52 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.52 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | PREP | P48147 | 3/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12945058 | 0.91 | POLB (0.67) | POLBSMN1; SMN2HPGDNPC1TDP1 | |
| SCHEMBL17117487 | 0.87 | POLB (0.61) | POLBNPC1RAB9AARCACNA1G | |
| SCHEMBL26114259 | 0.87 | HPGD (0.60) | SMN1; SMN2HPGDNPC1TDP1KMT2A | |
| SCHEMBL26107974 | 0.86 | POLB (0.59) | POLBNPC1RAB9ACACNA1GCACNA1H | |
| SCHEMBL26113012 | 0.86 | POLB (0.59) | POLBNPC1RAB9ACACNA1GCACNA1H | |
| SCHEMBL26111732 | 0.86 | POLB (0.59) | POLBNPC1RAB9ACACNA1GCACNA1H | |
| SCHEMBL451085 | 0.82 | FFAR1 (0.57) | POLBSMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL1828872 | 0.82 | ALDH1A1 (0.68) | POLBRAB9ACHRM2CHRM4CHRM1 | |
| SCHEMBL16973965 | 0.82 | ALDH1A1 (0.68) | POLBRAB9ACHRM2CHRM4CHRM1 | |
| SCHEMBL12489580 | 0.82 | ALDH1A1 (0.68) | POLBRAB9ACHRM2CHRM4CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022133069-A1 | PEPTIDOMIMETIC MATRIPTASE 2 INHIBITORS AND USES THEREOF | DISC MEDICINE, INC. (US) | 2022-06-23 | — | — | WO | disclosed |