Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP1 | P24666 | 9/20 | 1.00 |
| ▸ | KDR | P35968 | 1/20 | 0.58 |
| ▸ | PTPN12 | Q05209 | 4/20 | 0.56 |
| ▸ | PTPN13 | Q12923 | 3/20 | 0.56 |
| ▸ | SSU72 | Q9NP77 | 3/20 | 0.56 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.54 |
| ▸ | PTPN6 | P29350 | 3/20 | 0.54 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.54 |
| ▸ | CNR2 | P34972 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5184424 | 0.82 | ACP1 (0.69) | ACP1KDRCNR2KDM4ENPC1 | |
| SCHEMBL5183680 | 0.81 | ACP1 (0.67) | ACP1KDRCNR2KDM4ENPC1 | |
| SCHEMBL5227514 | 0.79 | ACP1 (0.65) | ACP1KDRKDM4ENPC1RAB9A | |
| SCHEMBL651159 | 0.77 | KDR (0.74) | ACP1KDRKDM4ENPC1RAB9A | |
| SCHEMBL5184940 | 0.77 | ACP1 (0.62) | ACP1KDRKDM4ENPC1RAB9A | |
| SCHEMBL13365400 | 0.76 | KDM4E (0.62) | ACP1KDRKDM4ENPC1RAB9A | |
| SCHEMBL30858830 | 0.76 | KDM4E (0.62) | ACP1KDRKDM4ENPC1RAB9A | |
| SCHEMBL18291915 | 0.76 | ACP1 (0.68) | ACP1KDRCNR2KDM4ENPC1 | |
| SCHEMBL29221848 | 0.76 | KDM4E (0.62) | ACP1KDRKDM4ENPC1RAB9A | |
| SCHEMBL27866684 | 0.76 | NPC1 (0.80) | ACP1KDRKDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180170862-A1 | PROTEIN TYROSINE PHOSPHATASES OR SHP2 INHIBITORS AND USES THEREOF | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION | 2018-06-21 | — | — | US | disclosed |
| US-20180170861-A1 | SMALL MOLECULE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES AND USED THEREOF | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION | 2018-06-21 | — | — | US | disclosed |
| WO-2016196591-A1 | PROTEIN TYROSINE PHOSPHATASES OR SHP2 INHIBITORS AND USES THEREOF | INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION (US) | 2016-12-08 | — | — | WO | disclosed |
| WO-2016196569-A1 | SMALL MOLECULE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES AND USES THEREOF | INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION (US) | 2016-12-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180170861-A1 | SMALL MOLECULE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES AND USED THEREOF | PTPA, EPM2A, PTPRA | ACP1 66/4885KDR 4379/4885PTPN12 53/4885 |
| US-20180170862-A1 | PROTEIN TYROSINE PHOSPHATASES OR SHP2 INHIBITORS AND USES THEREOF | PTPA, PTPRA, PTPRCAP | ACP1 75/4885KDR 4210/4885PTPN12 45/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.